The effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitches

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dc.contributor.authorKaya, D.
dc.contributor.authorKucukaslan, I.
dc.contributor.authorAgaoglu, A. R.
dc.contributor.authorAy, S. S.
dc.contributor.authorSchaefer-Somi, S.
dc.contributor.authorEmre, B.
dc.contributor.authorBal, Y.
dc.date.accessioned2024-04-24T16:10:49Z
dc.date.available2024-04-24T16:10:49Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was designed to assess endocrine changes associated with termination of midterm pregnancy after use of two different protocols. For this purpose we compared the effects of aglepristone (AGL) alone and in combination with cloprostenol (CLO) on serum concentrations of progesterone (P-4), estradiol (E-2) and relaxin (RLN) measured at shortterm intervals during the abortion period in bitches. Fourteen pregnant bitches between day 25 and 32 of gestation were used in the study. In the AGL group (n = 7), aglepristone was administered solely (10 mg/kg body weight (BW), subcutaneously, once daily on two consecutive days) whereas in the AGL-CLO group (n = 7), aglepristone (dosage as in AGL group) and cloprostenol (1 mu g/kg BW, subcutaneously, same with aglepristone) were combined. All pregnancies were successfully terminated 5.2 1.6 days after initiation of treatments, which was significant in both groups (P> 0.05). At the time of the start of abortion (SA) and the end of abortion (EA), the mean P4 concentrations were 26.6 7.3 and 12.0 6.4 ng/ml in AGL group, and 2.7 0.7 and 0.9 0.1 ng/ml, in AGL-CLO group, respectively (P< 0.01). Serum E-2 concentrations were significantly higher (P< 0.05) in AGL group at 42, 48, 54 hand SA after initiation of treatment. In the AGL-CLO group, serum RLN concentrations did not significantly change from the initiation of treatment to EA (P> 0.05). However, markedly higher RLN concentrations (P< 0.05) were observed in the AGL group at 48 h (1.5 0.7 ng/ml) and at SA (1.6 0.5 ng/ml). The results of the present study indicate that changes in the hormonal concentrations affect the mechanism of abortion in different ways. Further in depth studies investigating changes in the expression of hormone receptors inside the ovary, endometrium and placenta might be helpful to our understanding of the endocrinological differences observed in this study. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.anireprosci.2014.03.002
dc.identifier.endpage217en_US
dc.identifier.issn0378-4320
dc.identifier.issn1873-2232
dc.identifier.issue3-4en_US
dc.identifier.pmid24703776
dc.identifier.scopus2-s2.0-84899491060
dc.identifier.scopusqualityQ1
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.1016/j.anireprosci.2014.03.002
dc.identifier.urihttps://hdl.handle.net/11468/15124
dc.identifier.volume146en_US
dc.identifier.wosWOS:000336471100018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofAnimal Reproduction Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAglepristoneen_US
dc.subjectBitchesen_US
dc.subjectCloprostenolen_US
dc.subjectHormonal Changesen_US
dc.subjectInduction Of Abortionen_US
dc.titleThe effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitchesen_US
dc.titleThe effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitches
dc.typeArticleen_US

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