Risk factors affecting morbidity in typhoid enteric perforation

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dc.contributor.authorGedik, E.
dc.contributor.authorGirgin, S.
dc.contributor.authorTacyildiz, I. H.
dc.contributor.authorAkgun, Y.
dc.date.accessioned2024-04-24T16:01:53Z
dc.date.available2024-04-24T16:01:53Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction Typhoid enteric perforation is a cause of high morbidity and mortality. This study aim is to determine the factors affecting morbidity in patients with typhoid enteric perforation. Materials and methods Ninety-six patients with typhoid enteric perforation were reviewed. The variables are defined as follows: Age, gender, complaints, perforation-operation interval, typhoid fever treatment before the perforation or not, white blood cell (WBC) count, hemoglobin level (Hgb), intraoperative peritonitis intensity, the number of perforations, and type of surgery were examined. To determine the independent risk factors that might affect morbidity in typhoid enteric perforation, we made use of multivariate logistic regression analysis. Results Nine variables were applied the univariate analysis, which were greater than 30 years (P = 0.218), male gender (P = 0.02), preoperative treatment (P = 0.147), less than or equal to 48 h perforation-operation interval (P = 0.013), greater than 4,000 K/UL WBC (P = 0.388), less than 8 g/dL Hgb (P = 0.026), greater than 29 Mannheim Peritonitis Index (P < 0.0001), multiple perforation number (P = 0.614), and primary repair (P = 0.105). Logistic regression analysis showed that Mannheim Peritonitis Index (P = 0.014) and perforation-operation interval (P = 0.047) were defined as independent risk factors affecting morbidity. Conclusions If liquid electrolyte, blood, antibiotics, and parenteral nutrition are applied in typhoid enteric perforation cases adequately, then severe peritonitis becomes an independent risk factor that affects morbidity. Early diagnosis and appropriate surgery type would decrease morbidity and mortality.en_US
dc.identifier.doi10.1007/s00423-007-0244-8
dc.identifier.endpage977en_US
dc.identifier.issn1435-2443
dc.identifier.issue6en_US
dc.identifier.pmid18026981
dc.identifier.scopus2-s2.0-53549130468
dc.identifier.scopusqualityQ2
dc.identifier.startpage973en_US
dc.identifier.urihttps://doi.org/10.1007/s00423-007-0244-8
dc.identifier.urihttps://hdl.handle.net/11468/14464
dc.identifier.volume393en_US
dc.identifier.wosWOS:000259819300021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofLangenbecks Archives of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTyphoid Enteric Perforationen_US
dc.subjectRisk Factorsen_US
dc.subjectMorbidityen_US
dc.titleRisk factors affecting morbidity in typhoid enteric perforationen_US
dc.titleRisk factors affecting morbidity in typhoid enteric perforation
dc.typeArticleen_US

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