Elevated Plasma Levels of N-terminal pro-Brain Natriuretic Peptide in Children with Acute Poststreptococcal Glomerulonephritis

Basit Öğe Kaydı
dc.contributor.authorTaskesen, Mustafa
dc.contributor.authorTaskesen, Tuncay
dc.contributor.authorKatar, Selahattin
dc.contributor.authorKaradede, Abduelaziz
dc.contributor.authorTas, Mehmet Ali
dc.date.accessioned2024-04-24T17:18:13Z
dc.date.available2024-04-24T17:18:13Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractAcute poststreptococcal glomerulonephritis (APSGN) is the most common prototype of acute glomerulonephritis in children, and is characterized by the sudden onset of gross hematuria, edema, hypertension and volume overload. Brain natriuretic peptide (BNP) is produced in both the brain and the heart. Its prohormone, proBNP, is cleaved to biologically active BNP and an inactive N-terminal peptide of proBNP (NT-proBNP). NT-proBNP is released predominantly from the ventricles in response to hypervolemia and pressure overload. We therefore investigated the relationship between NT-proBNP levels and cardiac functions of patients with APSGN. NT-proBNP levels were measured in 28 patients with APSGN (17 boys and 11 girls of 8.2 +/- 2.9 years old) and in 26 healthy children (control group). Echocardiograms were performed in both patient and control groups on admission, and only in the patient group two weeks later. Upon admission, the plasma NT-proBNP levels were higher in the patients than in the control group (8876.2 +/- 9650.8 vs 69.5 +/- 22.2 pg/mL, p < 0.001), and left ventricular dysfunction was detected in six patients. Moreover, NT-proBNP levels were significantly higher in the patients with left ventricular dysfunction than other patients (n = 22). There was no significant difference in the levels of NT-proBNP between the patient and control groups, after diuretic treatment of the patients. Plasma NT-proBNP levels were positively correlated with the severity of APSGN. Thus, NT-proBNP level may be a useful marker to assess the volume overload and cardiac function in the follow up of selected APSGN patients.en_US
dc.identifier.doi10.1620/tjem.217.295
dc.identifier.endpage298en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue4en_US
dc.identifier.pmid19346734
dc.identifier.scopus2-s2.0-66149111719
dc.identifier.scopusqualityQ1
dc.identifier.startpage295en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.217.295
dc.identifier.urihttps://hdl.handle.net/11468/18670
dc.identifier.volume217en_US
dc.identifier.wosWOS:000265197700006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Poststreptococcal Glomerulonephritisen_US
dc.subjectNt-Pro Bnpen_US
dc.subjectCardiac Functionen_US
dc.subjectChildrenen_US
dc.titleElevated Plasma Levels of N-terminal pro-Brain Natriuretic Peptide in Children with Acute Poststreptococcal Glomerulonephritisen_US
dc.titleElevated Plasma Levels of N-terminal pro-Brain Natriuretic Peptide in Children with Acute Poststreptococcal Glomerulonephritis
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu