The synthesis of boronic-imine structured compounds and identification of their anticancer, antimicrobial and antioxidant activities

Basit Öğe Kaydı
dc.contributor.authorPasa, Salih
dc.contributor.authorAydin, Safa
dc.contributor.authorKalayci, Sadik
dc.contributor.authorBoga, Mehmet
dc.contributor.authorAtlan, Metin
dc.contributor.authorBingul, Murat
dc.contributor.authorSahin, Fikrettin
dc.date.accessioned2024-04-24T16:15:20Z
dc.date.available2024-04-24T16:15:20Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBoronic acid compounds with different substituted groups were handled to synthesize various ligands encoded as B1, B2, B3, B4, B5, B6, B7 and B8. B5 and B7 were tested for the cytotoxic activity against the prostate cancer cells and it was found that the cell viability of cancer cells was decreased while most of the healthy cells could still be viable. 5 mu M solutions of B5 and B7 decreased the cell viability to 33% and 44% whereas healthy cells were 71% and 95%, respectively, after treatment. Antimicrobial properties were explored against the bacterial and fungal microorganisms with B1, B5 and B7. The inhibition zones were evaluated for all boronic structures, and the growth inhibition zones were determined in a range of 713 mm diameter for different microorganism species. Staphylococcus aureus was the common microorganism that three boronic compounds with imine ligands showed the activity. Antioxidant features of B2, B3, B4, B5, B6, B7 and B8 were investigated by different processes such as Beta-carotene bleaching (BCB), 2,2-diphenyl picryl hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and CUPric reducing antioxidant capacity (CUPRAC) methods. Significant antioxidant activity was achieved by the phenyl boronic based ligands and these compounds demonstrated as much activity as standards (alpha-Toc and BHT). In addition, all structures were applied properly without any decomposition during the experiments. They were rather stable both in aqueous media and solid state. (C) 2015 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpha.2015.11.003
dc.identifier.endpage48en_US
dc.identifier.issn2095-1779
dc.identifier.issn2214-0883
dc.identifier.issue1en_US
dc.identifier.pmid29403961
dc.identifier.scopus2-s2.0-84959501318
dc.identifier.scopusqualityQ1
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpha.2015.11.003
dc.identifier.urihttps://hdl.handle.net/11468/15758
dc.identifier.volume6en_US
dc.identifier.wosWOS:000369608900006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Pharmaceutical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe synthesis of boronic-imine structured compounds and identification of their anticancer, antimicrobial and antioxidant activitiesen_US
dc.titleThe synthesis of boronic-imine structured compounds and identification of their anticancer, antimicrobial and antioxidant activities
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu