Does hepcidin play a role in the pathogenesis of aphthae in Behcet's disease and recurrent aphthous stomatitis?

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dc.contributor.authorCicek, D.
dc.contributor.authorDagli, A. F.
dc.contributor.authorAydin, S.
dc.contributor.authorDogan, F. Baskaya
dc.contributor.authorDertlioglu, S. B.
dc.contributor.authorUcak, H.
dc.contributor.authorDemir, B.
dc.date.accessioned2024-04-24T17:11:43Z
dc.date.available2024-04-24T17:11:43Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackgroundAphthae constitute one of the major signs in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS). No scientific study has yet explored the relationship of hepcidins, which have antimicrobial effects, with RAS and BD. ObjectivesIn this study, we aimed to evaluate by immunohistochemistry whether hepcidin is synthesized by the salivary glands and to measure levels of prohepcidin and hepcidin (an antibacterial peptide) in the serum and saliva of patients with BD and RAS. MethodsThe study included 25 BD patients and 30 RAS patients, as well as a control group comprising 25 healthy individuals. Serum and saliva samples were collected at the same time from all subjects. Levels of prohepcidin and hepcidin were measured by ELISA. The presence of hepcidin in salivary glands was assessed by immunohistochemistry. ResultsHepcidin was localized in the striated ducts of the sublingual and parotid glands. Saliva prohepcidin and hepcidin levels were correlated with blood levels. Saliva prohepcidin levels were found to be lower in RAS patients than in BD patients and healthy controls (P<0.001 and P=0.007 respectively). In addition, RAS patients had lower saliva hepcidin levels than did the control group (P=0.03). ConclusionsThe lower serum and saliva prohepcidin and hepcidin concentrations found in RAS and BD patients indicate that hepcidin may be involved in the aetiopathogenesis of these diseases. Because it can be obtained non-invasively and easily, saliva may provide a useful alternative to serum in quantifying prohepcidin and hepcidin concentrations.en_US
dc.description.sponsorshipFirat University Research Project Unit [TF.11.81]en_US
dc.description.sponsorshipThis study was supported financially by the Firat University Research Project Unit (project number: TF.11.81). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/ei9HoP.en_US
dc.identifier.doi10.1111/jdv.12326
dc.identifier.endpage1506en_US
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue11en_US
dc.identifier.pmid24341321
dc.identifier.scopus2-s2.0-85006339964
dc.identifier.scopusqualityQ1
dc.identifier.startpage1500en_US
dc.identifier.urihttps://doi.org/10.1111/jdv.12326
dc.identifier.urihttps://hdl.handle.net/11468/17686
dc.identifier.volume28en_US
dc.identifier.wosWOS:000344380600014
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of The European Academy of Dermatology and Venereology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleDoes hepcidin play a role in the pathogenesis of aphthae in Behcet's disease and recurrent aphthous stomatitis?en_US
dc.titleDoes hepcidin play a role in the pathogenesis of aphthae in Behcet's disease and recurrent aphthous stomatitis?
dc.typeArticleen_US

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