Effects of intravitreal ropivacaine on retinal thickness and integrity in the guinea pig

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dc.contributor.authorOlmez, G
dc.contributor.authorCakmak, SS
dc.contributor.authorSoker, SI
dc.contributor.authorNergiz, Y
dc.contributor.authorYildiz, F
dc.date.accessioned2024-04-24T16:11:14Z
dc.date.available2024-04-24T16:11:14Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Retrobulbar anesthesia is widely used for ocular surgery. Ocular complications are possible when retrobulbar anesthesia is accidentally injected intravitreally. Objective: The aim of this study was to determine the relative retinal toxicities of ropivacaine hydrochloride, a local anesthetic, using various concentrations in guinea pigs. Methods: This randomized, investigator-masked, experimental study was conducted at the Department of Anesthesiology, Dicle University, Diyarbakir, Turkey. The right eyes of 18 guinea pigs were assigned to I of 3 treatment groups: 1%, 0.75%, or 0.5% ropivacaine. The right eye of each animal was injected intravitreally with 0.1 mL of 1%, 0.75%, or 0.5% ropivacaine. The left eye of each animal was injected with a balanced saline solution (control). The guinea pigs were euthanized 7 days after injection, and the retinal structures were examined using light microscopy. The total thickness of each retina was measured using an ocular micrometer. Results: No histologic abnormalities were observed in the control eyes. Retinal damage of most of the retinal section was seen in the eyes receiving study drug. The eyes injected with 0.5% ropivacaine had a generally intact appearance, with the exception of some atrophy and disorganization. Overall, the eyes injected with 1% ropivacaine had significantly more extensive retinal thinning compared with the eyes injected with 0.75% or 0.5% ropivacaine (both, P < 0.01). In the eyes injected with 0.75% or 1% ropivacaine, disorganization of the structure of the retinal layers and atrophy were noted on histopathology. The mean total thicknesses of the retina were significantly less in all ropivacaine-treated eyes compared with that in the controls (P < 0.001). Conclusions: In this small experimental study, ropivacaine had concentration dependent toxic effects on guinea pig retinas.en_US
dc.identifier.doi10.1016/j.curtheres.2005.08.005
dc.identifier.endpage400en_US
dc.identifier.issn0011-393X
dc.identifier.issue4en_US
dc.identifier.pmid24672138
dc.identifier.scopus2-s2.0-26444477338
dc.identifier.scopusqualityQ3
dc.identifier.startpage394en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2005.08.005
dc.identifier.urihttps://hdl.handle.net/11468/15318
dc.identifier.volume66en_US
dc.identifier.wosWOS:000231920000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherExcerpta Medica Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimental
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntravitrealen_US
dc.subjectRetinaen_US
dc.subjectRopivacaineen_US
dc.subjectToxicityen_US
dc.subjectGuinea Pigsen_US
dc.subjectAnimalen_US
dc.titleEffects of intravitreal ropivacaine on retinal thickness and integrity in the guinea pigen_US
dc.titleEffects of intravitreal ropivacaine on retinal thickness and integrity in the guinea pig
dc.typeArticleen_US

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