Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

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dc.contributor.authorYaman, Ferhan
dc.contributor.authorAcikan, Izzet
dc.contributor.authorDundar, Serkan
dc.contributor.authorSimsek, Sercan
dc.contributor.authorGul, Mehmet
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorKomorowski, James
dc.date.accessioned2024-04-24T17:18:27Z
dc.date.available2024-04-24T17:18:27Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health. Objective: The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats. Methods: The rats were randomly assigned to two groups of 21 rats each. The control group was fed a standard diet for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The ASI group was fed a diet containing 1.81 g/kg of ASI for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The calvarial bones of all the rats were then harvested for evaluation. Results: Osteoblasts and osteoclasts were detected at higher levels in the ASI group compared with the control group at days 7, 14, and 28 of the calvarial defect (P<0.05). New bone formation was detected at higher levels in the ASI group compared with the controls at day 28 (P<0.05). However, new bone formation was not detected at days 7 and 14 in both the groups (P>0.05). Conclusion: ASI supplementation significantly improved bone tissue healing in rats with critical-sized defects. This study demonstrated that ASI can enhance bone repair and has potential as a therapeutic regimen in humans.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.description.sponsorshipThe authors thank Nutrition 21 Inc (NY, USA) for providing ASI complex. This work was supported in part by the Turkish Academy of Sciences (KS).en_US
dc.identifier.doi10.2147/DDDT.S109271
dc.identifier.endpage2086en_US
dc.identifier.issn1177-8881
dc.identifier.pmid27390517
dc.identifier.scopus2-s2.0-84976545032
dc.identifier.scopusqualityQ1
dc.identifier.startpage2081en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S109271
dc.identifier.urihttps://hdl.handle.net/11468/18783
dc.identifier.volume10en_US
dc.identifier.wosWOS:000378917700006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArginine Silicate Inositolen_US
dc.subjectBone Healingen_US
dc.subjectOsteoblasten_US
dc.subjectOsteoclasten_US
dc.subjectCritical-Sized Defecten_US
dc.titleDietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric studyen_US
dc.titleDietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study
dc.typeArticleen_US

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