Ultrastructural evaluation of the effects of cinnamon on the nervus ischiadicus in diabetic rats

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dc.contributor.authorBahceci, Selen
dc.contributor.authorAluclu, Mehmet U.
dc.contributor.authorCanoruc, Naime
dc.contributor.authorBahceci, Mithat
dc.contributor.authorAkkus, Murat
dc.contributor.authorBaran, Sedat
dc.contributor.authorGokalp, Deniz
dc.date.accessioned2024-04-24T17:40:00Z
dc.date.available2024-04-24T17:40:00Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the effects of oral cinnamon supplementation on the nervus ischiadicus at the electron microscopical level in rats. Methods: This study was performed between 20042006 in Dicle University School of Medicine, Diyarbakir, Turkey in 15 adult Sprague-Dawley rats. Rats were divided into 3 groups; control (C) (n=5), diabetic without cinnamon (D) (n=5), and diabetic with cinnamon (D-C) (n=5). Diabetes was induced with intraperitoneal alloxan administration. All diabetic rats were treated with human insulin. AN rats were fed with standard pellet chow. The D-C group rats were fed with standard pellet chow plus Cinnamomum cassia at the dose of 400mg/kg. All rats were sacrificed after 3 months and we obtained the nervus ischiadicus of all rats. Contrast stained thin sections evaluated by Jeol-TEM-1010 electron microscope, were not statistically different in both groups and photo samples were obtained. Results: Mean blood glucose, hemoglobin AlC, and lipid profile were not statistically different in both groups. Marked detachment of myelin lamellae at Schmidt-Lanterman clefts, lysis in cristae mitochondrialis and degenerative changes, severe dispersion of organelles in neurolemma, mesoaxon region, and remarkable edema at the endoneurium were found in diabetic rats. On the contrary, mesoaxon, nucleus, nucleolus and myelin sheet were almost of normal appearance at the ultra-structural level in the D-C group. Conclusions: Cinnamon extracts may have beneficial effects on the development of diabetic neuropathy in alloxan induced diabetic rats.en_US
dc.identifier.endpage342en_US
dc.identifier.issn1319-6138
dc.identifier.issue4en_US
dc.identifier.pmid21048647
dc.identifier.scopus2-s2.0-71949110635
dc.identifier.scopusqualityQ3
dc.identifier.startpage338en_US
dc.identifier.urihttps://hdl.handle.net/11468/21513
dc.identifier.volume14en_US
dc.identifier.wosWOS:000272519100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherRiyadh Armed Forces Hospitalen_US
dc.relation.ispartofNeurosciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleUltrastructural evaluation of the effects of cinnamon on the nervus ischiadicus in diabetic ratsen_US
dc.titleUltrastructural evaluation of the effects of cinnamon on the nervus ischiadicus in diabetic rats
dc.typeArticleen_US

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