Comparison of two different regimens of combined interferon-?2A and lamivudine therapy in children with chronic hepatitis B infection

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0002-8390-5109en_US
dc.authorid0000-0002-3133-9846en_US
dc.authorid0000-0001-6114-9210en_US
dc.authorid0000-0002-6721-4105en_US
dc.authorid0000-0001-8484-1285en_US
dc.authorid0000-0002-8113-286Xen_US
dc.authorid0000-0001-9442-7790en_US
dc.contributor.authorKansu, Aydan
dc.contributor.authorDoğancı, Tumay
dc.contributor.authorAkman, Sezin A.
dc.contributor.authorArtan, Reha
dc.contributor.authorKuyucu, Necdet
dc.contributor.authorKalaycı, Ayhan Gazi
dc.contributor.authorDikici, Bünyamin
dc.contributor.authorDalgıç, Buket
dc.contributor.authorSelimoğlu, Ayşe
dc.contributor.authorKasırga, Erhun
dc.contributor.authorÖzkan, Tanju B.
dc.contributor.authorKuloğlu, Zarife
dc.contributor.authorAydoğdu, Sema
dc.contributor.authorBoşnak, Mehmet
dc.contributor.authorErtekin, Vildan
dc.contributor.authorTanır, Gönül
dc.contributor.authorHaspolat, Yusuf Kenan
dc.contributor.authorGirgin, Nurten
dc.contributor.authorYağcı, Raşit Vural
dc.date.accessioned2021-12-09T12:54:45Z
dc.date.available2021-12-09T12:54:45Z
dc.date.issued2006en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: To evaluate the efficacy of two regimens of combined interferon-alpha2a (IFN-alpha2a) and lamivudine (3TC) therapy in childhood chronic hepatitis B. Methods: A total of 177 patients received IFN-alpha2a, 9 million units (MU)/m2 for 6 months. In group I (112 patients, 8.7 +/- 3.5 years), 3TC (4 mg/kg/day, max 100 mg) was started simultaneously with IFN-alpha2a, in group II (65 patients, 9.6 +/- 3.8 years) 3TC was started 2 months prior to IFN-alpha2a. 3TC was continued for 6 months after antiHBe seroconversion or stopped at 24 months in nonresponders. Results: Baseline alanine aminotransferase (ALT) was 134.2 +/- 34.1 and 147.0 +/- 45.3; histological activity index (HAI) was 7.4 +/- 2.7 and 7.1 +/- 2.3; and HBV DNA levels were above 2,000 pg/ml in 76% and 66% of patients in groups I and II, respectively (P > 0.005). Complete response was 55.3% and 27.6% in groups I and II, respectively (P < 0.01). AntiHBe seroconversion was higher and earlier, and HBV DNA clearance was earlier in group I (P < 0.05). HBsAg clearance was 12.5% and 4.6% and antiHBs seroconversion was 9.8% and 6.2% in groups I and II, respectively (P > 0.05). Breakthrough occurred in 17.9% and 24.6%; breakthrough times were 15.9 +/- 4.6 and 14.1 +/- 5.1 months; and relapse rates were 6.8% and none in groups I and II, respectively (P > 0.05, P > 0.05, P > 0.05). Responders had higher HAI (HAI > 6) and higher pre-treatment ALT than non-responders. Conclusion: Simultaneous 3TC+IFN-alpha2a yields a higher response and earlier antiHBe seroconversion and viral clearance than consecutive combined therapy. Relapse rate is low. Predictors of response are high basal ALT and high HAI scores. 3TC can be administered for 24 months without any side effect and breakthrough rate is comparable with previous studies.en_US
dc.identifier.citationKansu, A., Doğancı, T., Akman, S. A., Artan, R., Kuyucu, N., Kalaycı, A. G. ve diğerleri. (2006). Comparison of two different regimens of combined interferon-α2A and lamivudine therapy in children with chronic hepatitis B infection. Antiviral Therapy, 11(2), 255-261.en_US
dc.identifier.doi10.1177/135965350601100203
dc.identifier.endpage261en_US
dc.identifier.issn1359-6535
dc.identifier.issue2en_US
dc.identifier.pmid16640106
dc.identifier.scopus2-s2.0-33645511904
dc.identifier.scopusqualityQ3
dc.identifier.startpage255en_US
dc.identifier.urihttps://hdl.handle.net/11468/8394
dc.identifier.volume11en_US
dc.identifier.wosWOS:000236640500013
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDikici, Bünyamin
dc.institutionauthorBoşnak, Mehmet
dc.institutionauthorHaspolat, Yusuf Kenan
dc.language.isoenen_US
dc.publisherInternational Medical Pressen_US
dc.relation.ispartofAntiviral Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterferon-α2Aen_US
dc.subjectChildrenen_US
dc.subjectHepatitis Ben_US
dc.subjectLamivudineen_US
dc.subjectInfectionen_US
dc.titleComparison of two different regimens of combined interferon-?2A and lamivudine therapy in children with chronic hepatitis B infectionen_US
dc.titleComparison of two different regimens of combined interferon-?2A and lamivudine therapy in children with chronic hepatitis B infection
dc.typeArticleen_US

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