Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

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dc.authorid0000-0002-4337-9327en_US
dc.contributor.authorVarisli, Lokman
dc.contributor.authorCen, Osman
dc.contributor.authorVlahopoulos, Spiros
dc.date.accessioned2021-07-14T12:45:37Z
dc.date.available2021-07-14T12:45:37Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractChloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell. In addition to affecting cellular metabolism and bioenergetic flow equilibrium, autophagy plays a pivotal role at the interface between inflammation and cancer progression. Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system. In this article, we will review the work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy.en_US
dc.identifier.citationVarisli, L., Cen, O. ve Vlahopoulos, S. (2020). Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways. Immunology, 159(3), 257-278.en_US
dc.identifier.doi10.1111/imm.13160
dc.identifier.endpage278en_US
dc.identifier.issn0019-2805
dc.identifier.issn1365-2567
dc.identifier.issue3en_US
dc.identifier.pmid31782148
dc.identifier.scopus2-s2.0-85076891420
dc.identifier.scopusqualityQ1
dc.identifier.startpage257en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/imm.13160
dc.identifier.urihttps://hdl.handle.net/11468/7235
dc.identifier.volume159en_US
dc.identifier.wosWOS:000503767700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorVarisli, Lokman
dc.institutionauthorCen, Osman
dc.language.isoenen_US
dc.publisherIMMUAen_US
dc.relation.ispartofImmunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutophagyen_US
dc.subjectChloroquineen_US
dc.subjectDrug repurposingen_US
dc.subjectInflammationen_US
dc.subjectlysosomeen_US
dc.subjectNeoplasmen_US
dc.titleDissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathwaysen_US
dc.titleDissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways
dc.typeArticleen_US

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