Assessment of left ventricular systolic and diastolic function with conventional and tissue Doppler echocardiography imaging techniques in patients administered tyrosine kinase inhibitor

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dc.contributor.authorAlihanoglu, Yusuf Izzettin
dc.contributor.authorKaya, Zeynettin
dc.contributor.authorAri, Hatem
dc.contributor.authorKaraarslan, Sukru
dc.contributor.authorYildiz, Bekir Serhat
dc.contributor.authorKaranfil, Mustafa
dc.contributor.authorYazici, Mehmet
dc.date.accessioned2024-04-24T17:27:47Z
dc.date.available2024-04-24T17:27:47Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to use echocardiographic techniques to determine the possible cardiotoxic effects of low molecular weight tyrosine-kinase inhibitors (TKI) in patients receiving the therapy for the first time. Study design: Thirty patients (17 females; 13 males; mean age 49 +/- 16; range 22 to 76 years) who met the exclusion criteria and were diagnosed as having malignancy were enrolled. All patients underwent conventional echocardiography and tissue Doppler imaging (TDI) prior to the treatment. The conventional echocardiogram was repeated 2 months later as the patients were concurrently receiving therapy. Myocardial Performance Index was obtained by conventional echocardiography and by TDI techniques to evaluate left ventricular systolic and diastolic function. Results: Statistically significant increase occurred in mean left ventricle (LV) end-systolic volume. However, there was significant decrease in both mean LV ejection fraction and LV stroke volume values (64 +/- 3, 62 +/- 4, p=0.000 and 67 +/- 13, 61 +/- 13, p=0.000, respectively). Anterior wall Em/Am ratio measured by using the TDI technique was significantly decreased at the end of two months (0.99 +/- 0.49, 0.90 +/- 0.41, p=0.03). In addition, decreases were determined in Sm values obtained from all of four LV walls and also in mean Sm value, but this decrease was significant only for the lateral wall Sm measurement (12.8 +/- 2.9, 11.6 +/- 2.3, p=0.004). Conclusion: Tyrosine-kinase inhibitors therapy can be administered safely to patients without predisposing factors for cardiotoxicity in short treatment intervals, and low molecular TKIs may cause subtle or clinically significant cardiotoxicity following the treatment period even in patients without predisposing factors for cardiotoxicity, so clinicians should consider this possibility.en_US
dc.identifier.doi10.5543/tkda.2012.53896
dc.identifier.endpage605en_US
dc.identifier.issn1016-5169
dc.identifier.issue7en_US
dc.identifier.pmid23363943
dc.identifier.startpage597en_US
dc.identifier.trdizinid144022
dc.identifier.urihttps://doi.org/10.5543/tkda.2012.53896
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/144022
dc.identifier.urihttps://hdl.handle.net/11468/20195
dc.identifier.volume40en_US
dc.identifier.wosWOS:000421848500006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectEchocardiographyen_US
dc.subjectDoppleren_US
dc.subjectElasticity Imaging Techniquesen_US
dc.subjectHeart Failure/Chemically Induceden_US
dc.subjectDrug Interactionsen_US
dc.subjectNeoplasms/Drug Therapyen_US
dc.subjectProtein Tyrosine Kinases/Antagonists & Inhibitorsen_US
dc.subjectVentricular Functionen_US
dc.subjectLeften_US
dc.titleAssessment of left ventricular systolic and diastolic function with conventional and tissue Doppler echocardiography imaging techniques in patients administered tyrosine kinase inhibitoren_US
dc.titleAssessment of left ventricular systolic and diastolic function with conventional and tissue Doppler echocardiography imaging techniques in patients administered tyrosine kinase inhibitor
dc.typeArticleen_US

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