Histopathologic and Urodynamic Effects of the Anticholinergic Drugs Oxybutynin, Tolterodine, and Trospium on the Bladder

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dc.contributor.authorOrgen, Seyfettin
dc.contributor.authorDeliktas, Hasan
dc.contributor.authorSahin, Hayrettin
dc.contributor.authorGedik, Abdullah
dc.contributor.authorNergis, Yusuf
dc.date.accessioned2024-04-24T17:11:48Z
dc.date.available2024-04-24T17:11:48Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: This study aimed to evaluate the effects of intravesical instillation of the anticholinergic drugs oxybutynin, tolterodine, and trospium on bladder capacity and histopathological changes in the bladder mucosa. Methods: The study included 20 male New Zealand white rabbits that were randomly allocated to four groups of five. In the oxybutynin, tolterodine, and trospium groups, the drugs used were 1 mg/kg of crushed tablet mixed with 5 mL of saline, instilled intravesically once per day for 4 weeks. The control group was administered only 5 mL of saline once per day for 4 weeks. Urodynamic measurement of the bladder was made before and after treatment. At the end of the treatment the animals were killed and the bladders were evaluated histopathologically. Results: There were no significant differences between pre- and post-treatment bladder capacity in any of the groups (P>0.05). Histopathological evaluation showed that the mucosal epithelium was intact and there was minor inflammation in the control group and oxybutynin group (P>0.05), whereas there was destruction of the mucosal epithelium and findings of diffuse inflammation in the tolterodine (P=0.014) and trospium (P=0.014) groups. Conclusion: Intravesical oxybutynin treatment was observed to be safe; however, a single daily dose of oxybutynin may not be sufficient to increase bladder capacity. Intravesical use of trospium and tolterodine at high doses caused epithelial destruction and diffuse inflammation in the bladder mucosa. The irritation associated with epithelial destruction and inflammation prevented an increase in bladder capacity.en_US
dc.identifier.doi10.1111/luts.12096
dc.identifier.endpage56en_US
dc.identifier.issn1757-5664
dc.identifier.issn1757-5672
dc.identifier.issue1en_US
dc.identifier.pmid28120444
dc.identifier.scopus2-s2.0-84924112317
dc.identifier.scopusqualityQ2
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.1111/luts.12096
dc.identifier.urihttps://hdl.handle.net/11468/17726
dc.identifier.volume9en_US
dc.identifier.wosWOS:000396369200009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofLuts-Lower Urinary Tract Symptoms
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticholinergic Drugsen_US
dc.subjectBladder Capacityen_US
dc.subjectHistopathologyen_US
dc.subjectIntravesical Instillationen_US
dc.subjectRabbitsen_US
dc.titleHistopathologic and Urodynamic Effects of the Anticholinergic Drugs Oxybutynin, Tolterodine, and Trospium on the Bladderen_US
dc.titleHistopathologic and Urodynamic Effects of the Anticholinergic Drugs Oxybutynin, Tolterodine, and Trospium on the Bladder
dc.typeArticleen_US

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