Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action

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dc.authorid0000-0002-3999-620Xen_US
dc.authorid0000-0002-4656-8254en_US
dc.authorid0000-0003-4506-5265en_US
dc.authorid0000-0003-3342-702Xen_US
dc.authorid0000-0003-0578-2761en_US
dc.authorid0000-0003-4163-9962en_US
dc.authorid0000-0003-2904-160Xen_US
dc.authorid0000-0003-4262-0323en_US
dc.contributor.authorOğuz, Mehmet
dc.contributor.authorKalay, Erbay
dc.contributor.authorAkocak, Süleyman
dc.contributor.authorNocentini, Alessio
dc.contributor.authorLolak, Nebih
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2024-03-21T11:38:42Z
dc.date.available2024-03-21T11:38:42Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractA series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides. The obtained novel compounds were investigated as inhibitors of six human (h) isoforms of carbonic anhydrases (CA, EC 4.2.1.1). Their antioxidant profile was assayed by various bioanalytical methods. The calix[4]azacrown substituted sulphonamide Schiff bases were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes, associated with several diseases such as Alzheimer, Parkinson, and pigmentation disorders. The new sulphonamides showed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes. However, some of them possessed relevant antioxidant activity, comparable with standard antioxidants used in the study.en_US
dc.identifier.citationOğuz, M., Kalay, E., Akocak, S., Nocentini, A., Lolak, N., Boğa, M. ve diğerleri. (2020). Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 1215-1223.en_US
dc.identifier.doi10.1080/14756366.2020.1765166
dc.identifier.endpage1223en_US
dc.identifier.issn1475-6366
dc.identifier.issue1en_US
dc.identifier.pmid32401067
dc.identifier.scopus2-s2.0-85084626416
dc.identifier.scopusqualityQ1
dc.identifier.startpage1215en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/14756366.2020.1765166
dc.identifier.urihttps://hdl.handle.net/11468/13674
dc.identifier.volume35en_US
dc.identifier.wosWOS:000532584700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectCalix[4]azacrownen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory actionen_US
dc.titleSynthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
dc.typeArticleen_US

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