Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method

Basit Öğe Kaydı
dc.authorid0000-0003-0225-0516en_US
dc.authorid0000-0002-0703-2270en_US
dc.authorid0000-0001-7595-9417en_US
dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorKılıç, Abdulkadir
dc.contributor.authorAslan, Mehmet
dc.contributor.authorÖnal, Günay
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2024-03-06T12:02:37Z
dc.date.available2024-03-06T12:02:37Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Ziya Gökalp Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümüen_US
dc.description.abstractObjectives: The anticoagulant drug edoxaban has a blood thinning mechanism of action. In this study, a pencil graphite electrode was electrochemically activated at + 1.4 V for 60 s. in a Britton-Robinson (pH 9.0) supporting electrolyte solution. Evidence acquisition: A simple, fast, and sensitive electrochemical procedure was developed using cyclic voltammetry and square wave voltammetry techniques. It was observed that edoxaban gave a good oxidation signal with cyclic voltammetry technique at a potential of + 0.98 V (vs. Ag/AgCl). Results: This procedure showed a linear response in a Britton-Robinson (pH 9.0) media within the concentration range of 0.2–1.8 µM and limit of detection (LOD) and the limit of quantification (LOQ) values were determined to be 0.073 μM (0.133 μg mL−1) and 0.243 μM (0.443 μg mL−1), respectively. Conclusion: The method developed in this study was successfully applied to drug and urine samples. The developed voltammetric method was highly selective and gave satisfactory recovery results in urine and pharmaceutical samples. The results of the voltammetric method were compared with the spectroscopic method and it was determined that the results were compatible.en_US
dc.identifier.citationKılıç, A., Aslan, M., Önal, G. ve Levent, A. (2023). Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method. DARU, Journal of Pharmaceutical Sciences, 31(2), 233-241.en_US
dc.identifier.doi10.1007/s40199-023-00478-8
dc.identifier.endpage241en_US
dc.identifier.issn1560-8115
dc.identifier.issue2en_US
dc.identifier.pmid37695455
dc.identifier.scopus2-s2.0-85170364719
dc.identifier.scopusqualityQ1
dc.identifier.startpage233en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s40199-023-00478-8
dc.identifier.urihttps://hdl.handle.net/11468/13532
dc.identifier.volume31en_US
dc.identifier.wosWOS:001063380600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslan, Mehmet
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofDARU, Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticoagulanten_US
dc.subjectEdoxabanen_US
dc.subjectPencil graphite electrodeen_US
dc.subjectVoltammetryen_US
dc.titleFirstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric methoden_US
dc.titleFirstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode.pdf
Boyut:
2.33 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Matematik ve Fen Bilimleri Eğitimi Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu