Protective Effects of Carvacrol Against Methotrexate-induced Liver Toxicity in Rats

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dc.contributor.authorBozkurt, M.
dc.contributor.authorBodakci, M. N.
dc.contributor.authorTurkcu, G.
dc.contributor.authorKuyumcu, M.
dc.contributor.authorAkkurt, M.
dc.contributor.authorSula, B.
dc.contributor.authorEm, S.
dc.date.accessioned2024-04-24T16:24:15Z
dc.date.available2024-04-24T16:24:15Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground : To investigate whether carvacrol (CAR) pretreatment reduces the severity of methotrexate (MTX)-induced hepatotoxicity in rats. Methods : A total of 24 rats were equally divided into three groups : group I, control; group II, MTX-treated; and group III, CAR+MTX-treated. On Day 1 group III received a one-time intraperitoneal dose of CAR (73 mg/kg), and on Day 2 both groups II and III received a single dose of intraperitoneal MTX (20 mg/kg). The rats were then sacrificed so to harvest blood and liver tissue samples to determine malondialdehyde (MDA), total antioxidant capacity (TAS), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphata.se (ALP) levels. Histological specimens were examined via light microscopy. Results : Levels of MDA, ALT, AST and ALP in rat liver tissue samples were significantly higher in the MTX-treated group relative to the control group. However, TAS was significantly reduced in the MTX-treated group when compared to controls. Pretreating rats with CAR counteracted the effect of MTX exposure as MDA was significantly decreased and TAS was elevated in liver tissues when contrasted with the MTX-treated group. Furthermore, histological examination demonstrated significant liver injury in the MTX-treated group versus the CAR+MTX group. Conclusions : Pretreatment with CAR markedly diminished liver damage induced by MTX. Therefore, CAR administration preceding MTX treatment might be a promising therapeutic modality to prevent and/or lessen the extent of MTX-induced hepatotoxicity.en_US
dc.identifier.doi10.1080/00015458.2014.11681052
dc.identifier.endpage409en_US
dc.identifier.issn0001-5458
dc.identifier.issue6en_US
dc.identifier.pmid26021686
dc.identifier.scopus2-s2.0-84946567011
dc.identifier.scopusqualityQ3
dc.identifier.startpage404en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2014.11681052
dc.identifier.urihttps://hdl.handle.net/11468/16608
dc.identifier.volume114en_US
dc.identifier.wosWOS:000347511600009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Medical Belgicaen_US
dc.relation.ispartofActa Chirurgica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleProtective Effects of Carvacrol Against Methotrexate-induced Liver Toxicity in Ratsen_US
dc.titleProtective Effects of Carvacrol Against Methotrexate-induced Liver Toxicity in Rats
dc.typeArticleen_US

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