Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition

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dc.contributor.authorHaspolat, Kenan
dc.contributor.authorEce, Aydin
dc.contributor.authorGurkan, Fuat
dc.contributor.authorAtamer, Yildiz
dc.contributor.authorTutanc, Murat
dc.contributor.authorYolbas, Ilyas
dc.date.accessioned2024-04-24T16:11:02Z
dc.date.available2024-04-24T16:11:02Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Leptin has a key role in energy homeostasis and there may be a link between leptin and insulin-like growth factor-1 (IGF-I) system. The aim of this study was to analyze the relationships between long-lasting insufficient caloric intake (marasmus), leptin and IGF-1 system. Design and methods: The study group consisted of 30 marasmic children and control group included 28 healthy children. After an overnight fasting; leptin, insulin, IGF-1 and IGFBP-3 levels were measured. Results: Marasmic children had significantly lower body weight, height, mid-arm circumference (MAC), skinfold thickness, mean serum leptin, insulin, IGF-1 and IGFBP-3 levels compared with healthy subjects (P < 0.05). Serum IGF-1 and IGFBP-3 levels were significantly correlated with insulin, MAC and height Z score in patients (P < 0.05). In controls, significant positive correlations were found between BMI, 1GF-1 and leptin (P < 0.05). Conclusions: Energy malnutrition is characterized by the important decreases in the leptin, insulin, IGF-I and IGFBP-3 levels. Understanding details of these changes may lead to new therapeutic approaches in disease states associated with malnutrition. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiochem.2006.11.008
dc.identifier.endpage205en_US
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.issue3-4en_US
dc.identifier.pmid17208213
dc.identifier.scopus2-s2.0-33846200833
dc.identifier.scopusqualityQ2
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2006.11.008
dc.identifier.urihttps://hdl.handle.net/11468/15242
dc.identifier.volume40en_US
dc.identifier.wosWOS:000244193000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectMalnutritionen_US
dc.subjectIgf-1en_US
dc.subjectIgfbp-3en_US
dc.subjectLeptinen_US
dc.subjectInsulinen_US
dc.titleRelationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutritionen_US
dc.titleRelationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition
dc.typeArticleen_US

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