Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition
dc.contributor.author | Haspolat, Kenan | |
dc.contributor.author | Ece, Aydin | |
dc.contributor.author | Gurkan, Fuat | |
dc.contributor.author | Atamer, Yildiz | |
dc.contributor.author | Tutanc, Murat | |
dc.contributor.author | Yolbas, Ilyas | |
dc.date.accessioned | 2024-04-24T16:11:02Z | |
dc.date.available | 2024-04-24T16:11:02Z | |
dc.date.issued | 2007 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | Objectives: Leptin has a key role in energy homeostasis and there may be a link between leptin and insulin-like growth factor-1 (IGF-I) system. The aim of this study was to analyze the relationships between long-lasting insufficient caloric intake (marasmus), leptin and IGF-1 system. Design and methods: The study group consisted of 30 marasmic children and control group included 28 healthy children. After an overnight fasting; leptin, insulin, IGF-1 and IGFBP-3 levels were measured. Results: Marasmic children had significantly lower body weight, height, mid-arm circumference (MAC), skinfold thickness, mean serum leptin, insulin, IGF-1 and IGFBP-3 levels compared with healthy subjects (P < 0.05). Serum IGF-1 and IGFBP-3 levels were significantly correlated with insulin, MAC and height Z score in patients (P < 0.05). In controls, significant positive correlations were found between BMI, 1GF-1 and leptin (P < 0.05). Conclusions: Energy malnutrition is characterized by the important decreases in the leptin, insulin, IGF-I and IGFBP-3 levels. Understanding details of these changes may lead to new therapeutic approaches in disease states associated with malnutrition. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved. | en_US |
dc.identifier.doi | 10.1016/j.clinbiochem.2006.11.008 | |
dc.identifier.endpage | 205 | en_US |
dc.identifier.issn | 0009-9120 | |
dc.identifier.issn | 1873-2933 | |
dc.identifier.issue | 3-4 | en_US |
dc.identifier.pmid | 17208213 | |
dc.identifier.scopus | 2-s2.0-33846200833 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 201 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.clinbiochem.2006.11.008 | |
dc.identifier.uri | https://hdl.handle.net/11468/15242 | |
dc.identifier.volume | 40 | en_US |
dc.identifier.wos | WOS:000244193000010 | |
dc.identifier.wosquality | Q2 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.relation.ispartof | Clinical Biochemistry | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Children | en_US |
dc.subject | Malnutrition | en_US |
dc.subject | Igf-1 | en_US |
dc.subject | Igfbp-3 | en_US |
dc.subject | Leptin | en_US |
dc.subject | Insulin | en_US |
dc.title | Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition | en_US |
dc.title | Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition | |
dc.type | Article | en_US |