Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study

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dc.contributor.authorUzar, E.
dc.contributor.authorOzay, R.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorAktas, A.
dc.contributor.authorUlkay, M. B.
dc.contributor.authorUyar, M. E.
dc.contributor.authorErsoy, A.
dc.date.accessioned2024-04-24T17:14:37Z
dc.date.available2024-04-24T17:14:37Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group (p < 0.05). In addition, activities of superoxide dismutase and glutathione peroxidase were found to be significantly higher in the HCQ group than the control group (p < 0.05). There were significant decreases in nerve fiber diameter and myelin sheet thickness in the HCQ group compared with the control group (p < 0.05). These results revealed that HCQ might increase oxidative stress on sciatic nerve and muscle tissues of rats, which may correlate with axonal atrophy in sciatic nerves.en_US
dc.identifier.doi10.1177/0960327111433183
dc.identifier.endpage1073en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue10en_US
dc.identifier.pmid22751197
dc.identifier.scopus2-s2.0-84867557919
dc.identifier.scopusqualityQ2
dc.identifier.startpage1066en_US
dc.identifier.urihttps://doi.org/10.1177/0960327111433183
dc.identifier.urihttps://hdl.handle.net/11468/18097
dc.identifier.volume31en_US
dc.identifier.wosWOS:000309712900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydroxychloroquineen_US
dc.subjectNeuromyotoxicityen_US
dc.subjectNitric Oxideen_US
dc.subjectStereologyen_US
dc.subjectOxidative Stressen_US
dc.titleHydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical studyen_US
dc.titleHydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study
dc.typeArticleen_US

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