Effects of nicotine and vitamin E on 6-phosphogluconate dehydrogenase activity in some rat tissues in vivo and in vitro

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dc.contributor.authorCiftci, Mehmet
dc.contributor.authorYilmaz, Hayrullah
dc.contributor.authorCoban, T. Abdulkadir
dc.contributor.authorGul, Mustafa
dc.contributor.authorGumustekin, Kenan
dc.contributor.authorDane, Senol
dc.date.accessioned2024-04-24T17:07:47Z
dc.date.available2024-04-24T17:07:47Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate whether nicotine affects 6-phosphogluconate dehydrogenase (6PGD) enzyme activity in some rat tissues, and to see the modulatory effects of vitamin E on this effect in vivo. In addition, the effects of nicotine and vitamin E on 6PGD activity were also tested in vitro. The groups were: nicotine [0.5 mg/kg/day, intraperitoneal (i.p.)]; nicotine + vitamin E [75 mg/kg/day, intragastric (i.g.)]; and control group (receiving only vehicles). There were eight rats per group and supplementation period was 3 weeks. The results of in vivo study showed that nicotine activated the muscle, lungs, and testicular 6PGD enzyme activity but had no effect on heart and liver 6PGD activity. Also, nicotine + vitamin E activated the muscle, testicle, and liver 6PGD enzyme activity while this combination had no effect on heart, and lungs in vivo. When nicotine is administered with vitamin E the increase in 6PGD enzyme activity in muscle and testicles were lower. On the other hand the increase in 6PGD enzyme activity was eliminated by vitamin E in lungs, while 6PGD enzyme activity was increased by vitamin E, which was not affected by nicotine only. In vitro results correlated well with in vivo experimental results. Our results suggest that vitamin E may favourably increase 6PGD enzyme activity in liver in nicotine treated rats, while it has negligible effects on this enzyme activity in other tissues.en_US
dc.identifier.doi10.1080/14756360701505559
dc.identifier.endpage265en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue2en_US
dc.identifier.pmid18343913
dc.identifier.scopus2-s2.0-40949145674
dc.identifier.scopusqualityQ1
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1080/14756360701505559
dc.identifier.urihttps://hdl.handle.net/11468/16988
dc.identifier.volume23en_US
dc.identifier.wosWOS:000255597300016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject6-Phosphogluconate Dehydrogenaseen_US
dc.subjectMuscleen_US
dc.subjectHearten_US
dc.subjectLungsen_US
dc.subjectTesticleen_US
dc.subjectLiveren_US
dc.subjectNicotineen_US
dc.subjectVitamin Een_US
dc.subjectActivationen_US
dc.titleEffects of nicotine and vitamin E on 6-phosphogluconate dehydrogenase activity in some rat tissues in vivo and in vitroen_US
dc.titleEffects of nicotine and vitamin E on 6-phosphogluconate dehydrogenase activity in some rat tissues in vivo and in vitro
dc.typeArticleen_US

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