Inflammatory low back pain-associated malignancies mimicking spondylarthritis

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dc.authoridAlbayrak, Fatih/0000-0002-6052-3896
dc.authoridKoca, Suleyman Serdar/0000-0003-4995-430X
dc.contributor.authorAlbayrak, Fatih
dc.contributor.authorKisacik, Bunyamin
dc.contributor.authorGunduz, Ibrahim
dc.contributor.authorKudas, Ozlem
dc.contributor.authorKoc, Emrah
dc.contributor.authorZengin, Orhan
dc.contributor.authorKutlu, Nagehan Dik
dc.date.accessioned2025-02-22T14:09:07Z
dc.date.available2025-02-22T14:09:07Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives Inflammatory low back pain (IBP) is a typical feature of spondylarthritis (SpA). IBP can be caused by infections, drugs, and different malignancies. Among cancers, hematologic malignancies and solid tumors can cause IBD either paraneoplastically or through metastasis. In this study, we aimed to present the demographic and clinical characteristics of our patients who presented with IBP in the last 10 years and whose final diagnosis was malignancy. Methods Thirty-four patients who presented with inflammatory low back pain in the last 10 years and were diagnosed with malignancy as the final diagnosis were included in the study. Thirty-six patients, diagnosed as axial SpA, with similar age-sex ratio of 1:1 from each center were included as the control group. Results Hematologic malignancies were multiple myeloma, acute leukemia, and lymphoma in descending order. Solid tumors were breast cancer, lung cancer, bone tumors, prostate, colon, embryonal carcinoma, and malignancy of unknown primary. In malignancy-related low back pain, the hematologic/solid ratio was similar (18/16), the interval between symptom and diagnosis was shorter, and biomarkers' results such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum lactate dehydrogenase (LDH) levels were significantly higher than the control group. Conclusion Malignancy-related low back pain differs from SpA patients with a more severe clinical picture, higher acute phase reactants levels, and higher LDH values. Malignancies must be kept in mind in the differential diagnosis, and in order to validate our findings, the results of larger case series are needed, especially in terms of causative malignancies.en_US
dc.description.sponsorshipThanks to all the authors for their contributions.en_US
dc.identifier.doi10.1007/s10067-024-07141-w
dc.identifier.endpage3350en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue11en_US
dc.identifier.pmid39285007en_US
dc.identifier.scopus2-s2.0-85204008850en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3345en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-024-07141-w
dc.identifier.urihttps://hdl.handle.net/11468/29799
dc.identifier.volume43en_US
dc.identifier.wosWOS:001314127200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectHematological malignancyen_US
dc.subjectInflammatory low back painen_US
dc.subjectMalignancyen_US
dc.subjectSolid tumorsen_US
dc.subjectSpondylarthritisen_US
dc.titleInflammatory low back pain-associated malignancies mimicking spondylarthritisen_US
dc.typeArticleen_US

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