The XRCC1 and TP53 gene polymorphisms are associated with advanced-stage disease and early distant metastasis at diagnosis in non-small cell lung cancer

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dc.authorid0000-0003-0329-9047en_US
dc.authorid0000-0001-9100-5429en_US
dc.authorid0000-0002-3986-5517en_US
dc.contributor.authorKaraaǧaç, Mustafa
dc.contributor.authorGeredeli, Çaǧlayan
dc.contributor.authorYıldırım, Mahmut Selman
dc.contributor.authorAltınok, Tamer
dc.contributor.authorDede, İsa
dc.contributor.authorİnal, Ali
dc.contributor.authorZamani, Ayşe Gül
dc.date.accessioned2024-01-11T08:24:33Z
dc.date.available2024-01-11T08:24:33Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: Studies on single nucleotide polymorphisms (SNPs) in non‑small cell lung cancer (NSCLC) suggest that DNA repair capacity may have prognostic implications for disease recurrence and survival. However, there is no study investigating the relationship between SNPs and the risk of metastasis at the time of initial diagnosis in patients with NSCLC. Objective: This study aimed to investigate the potential predictive value of SNPs in detecting the risk of metastasis at the time of initial diagnosis and poor prognosis in patients with NSCLC. Material and Methods: In this prospective cohort study, we evaluated 275 patients with NSCLC. Analysis of SNPs from peripheral blood cells was performed by a polymerase chain reaction. Excision repair cross‑complementing group 1 (ERCC1)‑ Asn118Asn, excision repair cross‑complementing group 2 (ERCC2)‑Lys751Gln, X‑ray repair cross‑complementing group 1 (XRCC1)‑Arg399Gln, and tumor protein 53 (TP53)‑Arg72Pro polymorphisms were evaluated in conjunction with the development of metastasis. Results: The ERCC1 normal genotype, ERCC2 heterozygote genotype, XRCC1 normal genotype, and TP53 normal genotype were associated with a higher stage and more advanced‑stage disease at the time of initial diagnosis (P = 0.027, 0.005, <0.001, and 0.006, respectively). Also, XRCC1 normal genotype and TP53 normal genotype were associated with the risk of metastasis at the time of initial diagnosis (P = <0.001 and 0.002, respectively). Moreover, the XRCC1 normal genotype was associated with the risk of brain metastasis at the time of initial diagnosis (P = 0.031). Conclusions: We showed that SNPs are related to a higher stage and more advanced‑stage disease at the time of initial diagnosis in patients with NSCLC, and XRCC1 and TP53 gene polymorphisms are associated with the risk of metastasis. These results may contribute to the identification of high‑risk groups and may help to earlier diagnosis and treatment in patients with NSCLC.en_US
dc.identifier.citationKaraağaç, M., Geredeli, Ç., Yıldırım, M. S., Altınok, T., Dede, İ., İnal, A. ve diğerleri. (2023). The XRCC1 and TP53 gene polymorphisms are associated with advanced-stage disease and early distant metastasis at diagnosis in non-small cell lung cancer. Journal of Cancer Research and Therapeutics, 19(5), 1248-1254.en_US
dc.identifier.doi10.4103/jcrt.jcrt_1657_21
dc.identifier.endpage1254en_US
dc.identifier.issn0973-1482
dc.identifier.issue5en_US
dc.identifier.pmid37787291
dc.identifier.scopus2-s2.0-85173661476
dc.identifier.scopusqualityQ3
dc.identifier.startpage1248en_US
dc.identifier.urihttps://journals.lww.com/cancerjournal/fulltext/2023/19050/the_xrcc1_and_tp53_gene_polymorphisms_are.26.aspx
dc.identifier.urihttps://hdl.handle.net/11468/13173
dc.identifier.volume19en_US
dc.identifier.wosWOS:001099042700024
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİnal, Ali
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectMetastasisen_US
dc.subjectNon-small cell lung canceren_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subjectStageen_US
dc.titleThe XRCC1 and TP53 gene polymorphisms are associated with advanced-stage disease and early distant metastasis at diagnosis in non-small cell lung canceren_US
dc.titleThe XRCC1 and TP53 gene polymorphisms are associated with advanced-stage disease and early distant metastasis at diagnosis in non-small cell lung cancer
dc.typeArticleen_US

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