A detailed chemical and biological investigation of twelve allium species from Eastern Anatolia with chemometric studies

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dc.contributor.authorİzol, Ebubekir
dc.contributor.authorTemel, Hamdi
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorYener, İsmail
dc.contributor.authorÖlmez, Özge Tokul
dc.contributor.authorKaplaner, Erhan
dc.contributor.authorFırat, Mehmet
dc.contributor.authorErtaş, Abdülselam
dc.contributor.orcid0000-0002-4090-7227
dc.contributor.orcid0000-0001-9225-7425
dc.contributor.orcid0000-0002-0988-9462
dc.contributor.orcid0000-0002-2093-4949
dc.contributor.orcid0000-0002-2193-8386
dc.date.accessioned2024-04-24T15:59:21Z
dc.date.available2024-04-24T15:59:21Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractAllium species are widely consumed as food all over the world. The phenolic profile of ethanol extracts of aerial parts and roots of 12 Allium species, collected from five different Eastern Anatolia regions, were studied using LC-MS/MS. In vitro antioxidant, anticholinesterase, cytotoxic and antimicrobial activities were also tested. The multivariate analyses were performed using principal component and hierarchical cluster analyses. Seventeen of 27 standard compounds were detected in all Allium species. The major components were mainly identified as quinic acid, malic acid, vanillin, and p-coumaric acid. The aerial parts possessed better antioxidant activity than roots. Aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense exhibited high cytotoxic activity against DLD-1 colon cancer cell lines (IC50 12.5 mu g/mL). A. shatakiense and A. vineale demonstrated good antimicrobial activity against S. aureus and E. coli (MIC 75 mu g/mL). According to chemometric analysis, differences were detected between aerial parts and the roots. The aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense could be potent in the pharmaceutical industry while A. shatakiense and A. vineale in the food industry after further investigations.en_US
dc.description.sponsorshipResearch Fund of Dicle University (DuBAP) [ECZACILIK. 15.005]; Mugla Sitki Kocman University Research fund [15/116]en_US
dc.description.sponsorshipThis study is a part of E.I's M.Sc. thesis and was supported by the Research Fund of Dicle University (DuBAP) (Project number: ECZACILIK. 15.005). Mugla Sitki Kocman University Research fund is also acknowledged with the project number 15/116.en_US
dc.identifier.citationİzol, E., Temel, H., Yılmaz, M. A., Yener, İ., Ölmez, Ö. T., Kaplaner, E. ve diğerleri. (2021). A detailed chemical and biological investigation of twelve allium species from Eastern Anatolia with chemometric studies. Chemistry and Biodiversity, 18(1), 1-14.
dc.identifier.doi10.1002/cbdv.202000560
dc.identifier.endpage14
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue1en_US
dc.identifier.pmid33188649
dc.identifier.scopus2-s2.0-85097267505
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/cbdv.202000560
dc.identifier.urihttps://hdl.handle.net/11468/14001
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000560
dc.identifier.volume18en_US
dc.identifier.wosWOS:000596442200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİzol, Ebubekir
dc.institutionauthorTemel, Hamdi
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorYener, İsmail
dc.institutionauthorErtaş, Abdülselam
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllium speciesen_US
dc.subjectChemical compositionen_US
dc.subjectCytotoxic activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectChemometryen_US
dc.titleA detailed chemical and biological investigation of twelve allium species from Eastern Anatolia with chemometric studiesen_US
dc.titleA detailed chemical and biological investigation of twelve allium species from Eastern Anatolia with chemometric studies
dc.typeArticleen_US

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