Evaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ischemic stroke

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dc.contributor.authorOzdemir, Hasan Huseyin
dc.contributor.authorMungen, Bulent
dc.contributor.authorIlhan, Selcuk
dc.date.accessioned2024-04-24T17:18:07Z
dc.date.available2024-04-24T17:18:07Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Convulsive status epilepticus (CSE) is very rarely observed after ischaemic stroke. Sodium valproate (SV) is one of the agents used in the treatment of CSE, but its role still controversial, and its degree of efficacy in treating CSE that develops following stroke is unclear. Method: We evaluated 19 patients who were treated with intravenous (IV) SV (20 mg/kg, 2 mg/kg/h-12h) after diazepam. Patients' modified Rankin scores (mRS), SE types, and changes in biochemical parameters after treatment were assessed. Results: CSE was successfully treated in 12 (63.15%) patients. Side effects such as hypotension and allergic reactions were observed in two patients. Refractory SE development was observed in 5 (29.4%) patients with high mRS (>3). No significant deterioration in patients' laboratory evaluations, conducted before and after status, was observed. Conclusion: SV may be safe and effective in the treatment of CSE observed after ischaemic stroke, especially in patients with low mRS.en_US
dc.identifier.doi10.1590/0004-282X20150001
dc.identifier.endpage297en_US
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue4en_US
dc.identifier.pmid25992518
dc.identifier.scopus2-s2.0-84929331523
dc.identifier.scopusqualityQ3
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1590/0004-282X20150001
dc.identifier.urihttps://hdl.handle.net/11468/18612
dc.identifier.volume73en_US
dc.identifier.wosWOS:000354787600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAssoc Arquivos Neuro- Psiquiatriaen_US
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConvulsive Status Epilepticusen_US
dc.subjectIschaemic Strokeen_US
dc.subjectSodium Valproateen_US
dc.titleEvaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ischemic strokeen_US
dc.titleEvaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ischemic stroke
dc.typeArticleen_US

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