Comparison of 12-month courses of interferon-?-2b-lamivudine combination therapy and interferon-?-2b monotherapy among patients with untreated chronic hepatitis B

Basit Öğe Kaydı
dc.contributor.authorYalcin, K
dc.contributor.authorDegertekin, H
dc.contributor.authorYildiz, F
dc.contributor.authorCelik, Y
dc.date.accessioned2024-04-24T17:07:58Z
dc.date.available2024-04-24T17:07:58Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe compared the use of prolonged synchronous combination therapy with interferon (IFN)-alpha-2b and lamivudine with the use of IFN-alpha-2b monotherapy in patients with untreated hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection. Thirty-three patients received therapy with lamivudine (100 mg daily) and IFN-alpha-2b (10 million U 3 times per week) for 12 months; 16 patients received IFN-alpha-2b alone (10 million U 3 times per week for 12 months). The primary end point was sustained suppression of HBV DNA and HBeAg seroconversion, which was observed in 15 (45%) of 33 patients treated with combination therapy and in 3 (19%) of 16 patients treated with monotherapy (P = .133). Both therapeutic regimens were well tolerated. Combination therapy increased the rate of sustained suppression of HBeAg and resulted in significant improvement in Knodell histologic activity index scores, compared with monotherapy. However, there was no significant difference in rates of sustained suppression between the 2 groups at the end of follow-up.en_US
dc.identifier.doi10.1086/375085
dc.identifier.endpage1522en_US
dc.identifier.issn1058-4838
dc.identifier.issn1537-6591
dc.identifier.issue12en_US
dc.identifier.pmid12802750
dc.identifier.scopus2-s2.0-0037871938
dc.identifier.scopusqualityQ1
dc.identifier.startpage1516en_US
dc.identifier.urihttps://doi.org/10.1086/375085
dc.identifier.urihttps://hdl.handle.net/11468/17123
dc.identifier.volume36en_US
dc.identifier.wosWOS:000183460000003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofClinical Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleComparison of 12-month courses of interferon-?-2b-lamivudine combination therapy and interferon-?-2b monotherapy among patients with untreated chronic hepatitis Ben_US
dc.titleComparison of 12-month courses of interferon-?-2b-lamivudine combination therapy and interferon-?-2b monotherapy among patients with untreated chronic hepatitis B
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu