Diagnostic value of PET/CT in differentiating benign from malignant solitary pulmonary nodules

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dc.contributor.authorDalli, A.
dc.contributor.authorSen, H. Selimoglu
dc.contributor.authorCoskunsel, M.
dc.contributor.authorKomek, H.
dc.contributor.authorAbakay, O.
dc.contributor.authorSergi, C.
dc.contributor.authorTanrikulu, A. Cetin
dc.date.accessioned2024-04-24T17:33:29Z
dc.date.available2024-04-24T17:33:29Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Solitary pulmonary nodules (SPNs) are round or oval lesions with a clear border with the surrounding parenchymal tissue and a radiologic diameter smaller than 3 cm which are not associated with atelectasis, pneumonia, lymphadenopathy, or chest wall pathologies. The purpose of the present study was to evaluate the efficacy of positron emission tomography (PET) / computerized tomography (CT) in differentiating benign from malignant SPNs. Methods: In this retrospective study, 209 patients, who were diagnosed with SPN by thoracic CT and demonstrated positive or negative results for malignancy in the PET/CT examination between January 2007 and June 2010, were enrolled. Among the 91 patients who gave consent for interventional procedures, performed were bronchoscopic endobronchial biopsy in 10, transbronchial biopsy in 15, bronchoscopic brushing in 4, transthoracic needle biopsy in 11, video-assisted thoracoscopy (VATS) in 4, lobectomy in 22, pneumonectomy in 2, and wedge resection in 23. The materials were histo pathologically examined. Results: 129 (61.72%) of the SPN cases were benign and 80 (38.27%) malignant. The mean SUVmax value for the benign SPNs was 2.06 +/- 3.29 and 7.39 +/- 5.69 for the malignant SPNs (p=0.000). Positive correlation was found between the nodule diameter and risk for malignancy. A SUVmax value of 4 was found to have the best sensitivity and specificity. Conclusion: PET/CT was shown to be an accurate method in the differential diagnosis of benign from malignant solitary pulmonary nodules.en_US
dc.identifier.endpage941en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4en_US
dc.identifier.pmid24344020
dc.identifier.scopus2-s2.0-84893110663
dc.identifier.scopusqualityQ3
dc.identifier.startpage935en_US
dc.identifier.urihttps://hdl.handle.net/11468/20711
dc.identifier.volume18en_US
dc.identifier.wosWOS:000331593700019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalignant Tumoren_US
dc.subjectPositron Emission Tomographyen_US
dc.subjectSolitary Pulmonary Nodulesen_US
dc.subjectSuvmaxen_US
dc.titleDiagnostic value of PET/CT in differentiating benign from malignant solitary pulmonary nodulesen_US
dc.titleDiagnostic value of PET/CT in differentiating benign from malignant solitary pulmonary nodules
dc.typeArticleen_US

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