Histological evaluation of rat larynx in experimental polycystic ovary syndrome model

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dc.contributor.authorDeveci, Hande Senem
dc.contributor.authorDeveci, Ildem
dc.contributor.authorHabesoglu, Mehmet
dc.contributor.authorSurmeli, Mehmet
dc.contributor.authorKinis, Vefa
dc.contributor.authorEriman, Murat
dc.contributor.authorGunes, Pembegul
dc.date.accessioned2024-04-24T16:01:52Z
dc.date.available2024-04-24T16:01:52Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed at studying the histopathological effects of hyperandrogenemia and estrogen deficiency on larynx mucosa in experimentally designed polycystic ovary syndrome of female rats. Two groups of experimental polycystic ovary syndrome model were composed in healthy female rats by per oral letrozole administration of for 21 and 42 days. Also a control group which only took vehicle (saline) for 42 days was designed. Laryngeal mucosa and ovaries of all animals were examined histopathologically by light microscopy and the serum hormone levels were analyzed using a solid-phase, two-site chemiluminescent enzyme immunometric assay. Statistically significant edema, vascular engorgement, inflammation, cilia loss and differentiation of goblet cell distribution were observed when the control group and study groups were compared (p < 0.01). In serum hormonal analysis there was a significant increase in levels of androgens and decrease in levels of estrogens. In addition, polycystic appearance of ovaries in letrozole-administered groups and normal appearance of ovaries in control group have been proven histopathologically. Polycystic ovary syndrome which causes estrogen deficiency and hyperandrogenemia in fertile ages resulted in histopathological changes in laryngeal mucosa.en_US
dc.identifier.doi10.1007/s00405-012-1978-7
dc.identifier.endpage1950en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue8en_US
dc.identifier.pmid22407189
dc.identifier.scopus2-s2.0-84865042941
dc.identifier.scopusqualityQ1
dc.identifier.startpage1945en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-012-1978-7
dc.identifier.urihttps://hdl.handle.net/11468/14442
dc.identifier.volume269en_US
dc.identifier.wosWOS:000305979900010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLarynxen_US
dc.subjectHyperandrogenismen_US
dc.subjectHistopathologyen_US
dc.titleHistological evaluation of rat larynx in experimental polycystic ovary syndrome modelen_US
dc.titleHistological evaluation of rat larynx in experimental polycystic ovary syndrome model
dc.typeArticleen_US

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