Evaluation of outcome and prognostic factors in 739 patients with uterine cervix carcinoma: a single institution experience

Basit Öğe Kaydı
dc.contributor.authorTeke, Fatma
dc.contributor.authorYoney, Adnan
dc.contributor.authorTeke, Memik
dc.contributor.authorAdanas, Gultekin
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorTukcu, Gu
dc.contributor.authorEren, Bekir
dc.date.accessioned2024-04-24T17:24:56Z
dc.date.available2024-04-24T17:24:56Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim of the study: The aim of this retrospective chart review was to determine the long-term outcomes and identify prognostic factors that impact the survival of patients with cervical cancer. Material and methods: A retrospective chart review of 739 patients with International Federation of Gynaecology and Obstetrics (FIGO) stage I-IV cervical cancer treated with surgery, radiation or chemoradiation was performed. Patient charts were evaluated in terms of demographics, clinical outcomes, and survival. Disease-free survival (DFS) and overall survival (OS) were calculated with the Kaplan-Meier method, and differences in survival were compared with the log-rank test. Multivariate analysis was performed with a Cox proportional hazards model to determine the estimated hazard ratios (HR) with 95% confidence intervals (CI) for each prognostic factor. Results: The Cox proportional hazards model demonstrated that pelvic nodal metastasis (p = 0.018), parametrial invasion (p = 0.015), and presence of disease in the surgical margin (p = = 0.011) were all independent prognostic factors for OS. The 5-year OS rate of patients with negative pelvic lymph nodes was 67.1%, which was higher than the rate for those with positive nodes at 49.0% (p < 0.05). The 5-year OS rate was 54.3% for patients with metastasis to the parametrium, 79.2% with a cancer-free parametrium, 60.9% with a cancer-positive surgical margin, 85.4% with a cancer-negative surgical margin, and 64.3% with a 1-3 mm close surgical margin (p < 0.05). Conclusions: Assessing pelvic lymph nodes, the parametrium, and surgical margins is important for survival and may aid in better identifying patients who would derive greater benefits from receiving adjuvant therapies and more aggressive treatments.en_US
dc.identifier.doi10.5114/wo.2015.51418
dc.identifier.endpage136en_US
dc.identifier.issn1428-2526
dc.identifier.issn1897-4309
dc.identifier.issue2en_US
dc.identifier.pmid26034391
dc.identifier.scopus2-s2.0-84929413382
dc.identifier.scopusqualityQ2
dc.identifier.startpage130en_US
dc.identifier.urihttps://doi.org/10.5114/wo.2015.51418
dc.identifier.urihttps://hdl.handle.net/11468/19886
dc.identifier.volume19en_US
dc.identifier.wosWOS:000422085900008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofWspolczesna Onkologia-Contemporary Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCervical Canceren_US
dc.subjectParametrial Invasionen_US
dc.subjectPelvic Lymph Nodeen_US
dc.subjectPrognostic Factorsen_US
dc.subjectSurvivalen_US
dc.titleEvaluation of outcome and prognostic factors in 739 patients with uterine cervix carcinoma: a single institution experienceen_US
dc.titleEvaluation of outcome and prognostic factors in 739 patients with uterine cervix carcinoma: a single institution experience
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu