The protective role of glutamine against acute induced toxicity in rats

Basit Öğe Kaydı
dc.contributor.authorAydin, Mesut
dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorEkinci, Aysun
dc.contributor.authorUlger, Burak Veli
dc.contributor.authorYuksel, Murat
dc.contributor.authorBilik, Mehmet Zihni
dc.date.accessioned2024-04-24T17:20:34Z
dc.date.available2024-04-24T17:20:34Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractContext: Deltamethrin (DLM) is an insecticide commonly used to protect agricultural crops against pests. QT prolongation with malignant ventricular arrhythmias are amongst the most common cardiovascular complications. DLM intoxication cause decreased level of antioxidant enzymes. Glutamine is the precursor of glutathione which is an antioxidant and has been demonstrated to improve outcome after several critical illnesses. Objective: We hypothesized that glutamine, by means of antioxidant characteristics, may antagonize the cardiotoxic effects of DLM. Materials and methods: All experiments were performed on 8-week-old male Wistar albino rats. The rats were divided into following groups (n = 10); Group I: control, Group II: L-glutamine, Group III: DLM, Group IV: DLM and after 4 h L-glutamine. Total antioxidant status (TAS), total oxidant status (TOS) and parameter analyses were performed in cardiac tissue. Results: We found that TAS was higher and TOS lower in DLM group. We also found that interstitial edema and inflammatory cell infiltration was significantly more frequent in DLM group and QT and QTc of DLM group were higher than others. Discussion: Recent studies have shown that several special amino acids, such as glutamine, glycine, arginine and taurine, exhibit cytoprotective effect on the cardiocyte, and have established the cardioprotective properties of glutamine. Conclusion: In this study, we showed the protective role of glutamine against cardiotoxic effects of DLM in rats. This protective effect was confirmed by showing both tissue level improvement in oxidative stress markers and improvement in prolonged QT interval.en_US
dc.identifier.doi10.3109/15376516.2015.1025349
dc.identifier.endpage301en_US
dc.identifier.issn1537-6516
dc.identifier.issn1537-6524
dc.identifier.issue4en_US
dc.identifier.pmid25798648
dc.identifier.scopus2-s2.0-84940485209
dc.identifier.scopusqualityQ2
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.3109/15376516.2015.1025349
dc.identifier.urihttps://hdl.handle.net/11468/19135
dc.identifier.volume25en_US
dc.identifier.wosWOS:000361332600007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicology Mechanisms and Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmino Aciden_US
dc.subjectAntioxidanten_US
dc.subjectInsecticideen_US
dc.subjectOxidanten_US
dc.titleThe protective role of glutamine against acute induced toxicity in ratsen_US
dc.titleThe protective role of glutamine against acute induced toxicity in rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu