Can safe and long-term exposure to extremely low frequency (50 Hz) magnetic fi elds aff ect apoptosis, reproduction, and oxidative stress?

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dc.contributor.authorAkdag, Mehmet Zulkuf
dc.contributor.authorDasdag, Suleyman
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorUlukaya, Engin
dc.contributor.authorOral, Arzu Yilmaztepe
dc.contributor.authorCelik, Necla
dc.contributor.authorAksen, Feyzan
dc.date.accessioned2024-04-24T17:20:30Z
dc.date.available2024-04-24T17:20:30Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose : To determine whether 50 Hz extremely low frequency-magnetic fi elds (ELF-MF) aff ects apoptotic processes, oxidative damage, and reproductive characteristics such as sperm count and morphology in rat testes. Materials and methods : Thirty male Sprague-Dawley rats were used in the present study, which were divided into three groups (sham group, n = 10, and two experimental groups, n = 10 for each group). Rats in the experimental group were exposed to 100 and 500 mu T ELF-MF (2 h/day, 7 days/week, for 10 months) corresponding to exposure levels that are considered safe for humans. The same experimental procedures were applied to the sham group, but the ELF generator was turned off. Tissues from the testes were immunohistochemically stained for active (cleaved) caspase-3 in order to measure the apoptotic index by a semi-quantitative scoring system. The levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were also measured. Additionally, epididymal sperm count and sperm morphology was evaluated. Results : There were no signifi cant diff erences in the reproductive and oxidative stress parameters between the sham group and the exposed groups (p > 0.05). While no diff erence was observed between the fi nal apoptosis score of the sham and the 100 mu T ELF-MF group (p > 0.05), the fi nal apoptosis score was higher in the 500 mu T ELF-MF exposure group than in the sham group (p < 0.05). Conclusion : Long-term exposure to 100 mu T and 500 mu T ELF-MF did not aff ect oxidative or antioxidative processes, lipid peroxidation, or reproductive components such as sperm count and morphology in testes tissue of rats. However, long-term exposure to 500 mu T ELF-MF did aff ect active-caspase-3 activity, which is a well-known apoptotic indicator.en_US
dc.identifier.doi10.3109/09553002.2013.817705
dc.identifier.endpage1060en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue12en_US
dc.identifier.pmid23786626
dc.identifier.scopus2-s2.0-84890896395
dc.identifier.scopusqualityQ2
dc.identifier.startpage1053en_US
dc.identifier.urihttps://doi.org/10.3109/09553002.2013.817705
dc.identifier.urihttps://hdl.handle.net/11468/19093
dc.identifier.volume89en_US
dc.identifier.wosWOS:000329867500007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElf-Mfen_US
dc.subjectReproductionen_US
dc.subjectApoptosisen_US
dc.subjectOxidative Stressen_US
dc.titleCan safe and long-term exposure to extremely low frequency (50 Hz) magnetic fi elds aff ect apoptosis, reproduction, and oxidative stress?en_US
dc.titleCan safe and long-term exposure to extremely low frequency (50 Hz) magnetic fi elds aff ect apoptosis, reproduction, and oxidative stress?
dc.typeArticleen_US

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