Evaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study

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dc.contributor.authorOzler, Ali
dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorGoruk, Neval Yaman
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorBasarali, Mustafa Kemal
dc.contributor.authorAkdemir, Fatih
dc.date.accessioned2024-04-24T17:14:28Z
dc.date.available2024-04-24T17:14:28Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the protective effects of coenzyme Q(10) (CoQ(10)) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model. Methods: 48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ(10), torsion+CoQ(10), and detorsion+CoQ(10) groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ(10) groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ(10) groups. CoQ(10) was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion. Results: The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ(10), which is a potent antioxidant. Conclusions: Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ(10) could be useful for the protection of ovarian tissue before conservative surgery. (C) 2013 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000353425
dc.identifier.endpage106en_US
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue2en_US
dc.identifier.pmid23886769
dc.identifier.scopus2-s2.0-84884202785
dc.identifier.scopusqualityQ2
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.1159/000353425
dc.identifier.urihttps://hdl.handle.net/11468/17977
dc.identifier.volume76en_US
dc.identifier.wosWOS:000324358600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdnexal Torsionen_US
dc.subjectCoenzyme Q(10)en_US
dc.subjectOxidative Stressen_US
dc.titleEvaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Studyen_US
dc.titleEvaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study
dc.typeArticleen_US

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