Effects of increasing ratio of progesterone in estrogen/progesterone combination on total oxidant/antioxidant status in rat uterus and plasma

Basit Öğe Kaydı
dc.contributor.authorHekimoglu, Askin
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorKurcer, Zehra
dc.contributor.authorOcak, Ali Riza
dc.date.accessioned2024-04-24T16:00:17Z
dc.date.available2024-04-24T16:00:17Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe relationship between increasing ratio of progesterone in estrogen/progesterone combination and oxidative stress (OS) was investigated. Thirty non-pregnant Wistar Albino female rats were divided into five groups and bilaterally ovariectomized (Ovx) except sham group. Sham + 0.3 cc seaseme oil, Ovx + 0.3 cc seaseme oil, Ovx + estradiol propionate (E2) (1 mu g/kg), Ovx + E2 + medroxyprogesterone acetate (MPA) 1 mg/kg, Ovx + E2 + MPA 20 mg/kg. Hormones were applied for three consecutive days after 28 days of ovariectomy. Their uteri and blood samples were collected and nitric oxide (NO), malondialdehyde (MDA), total oxidative status (TOS) and total antioxidant capacity (TAC) levels were determined. E2 + MPA1 treatment decreased NO, MDA and TOS levels and increased TAC levels in uterus. Plasma NO levels elevated in all groups and MDA production increased due to E2 treatment when compared to ovariectomy. E2 + MPA20 treatment increased TOS levels, while TAC levels decreased when compared to ovariectomy in plasma. Using E2 plus low dose progesterone may prevent pathologies resourced of OS.en_US
dc.identifier.doi10.1007/s00404-009-1044-x
dc.identifier.endpage28en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue1en_US
dc.identifier.pmid19326135
dc.identifier.scopus2-s2.0-71449085691
dc.identifier.scopusqualityQ2
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-009-1044-x
dc.identifier.urihttps://hdl.handle.net/11468/14428
dc.identifier.volume281en_US
dc.identifier.wosWOS:000272017600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEstradiol Propionateen_US
dc.subjectMedroxyprogesterone Acetateen_US
dc.subjectOxidative Stressen_US
dc.subjectNitric Oxideen_US
dc.subjectMalondialdehydeen_US
dc.titleEffects of increasing ratio of progesterone in estrogen/progesterone combination on total oxidant/antioxidant status in rat uterus and plasmaen_US
dc.titleEffects of increasing ratio of progesterone in estrogen/progesterone combination on total oxidant/antioxidant status in rat uterus and plasma
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu