Effects of low-intensity microwave radiation on oxidant-antioxidant parameters and DNA damage in the liver of rats

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dc.contributor.authorAlkış, Mehmet Eşref
dc.contributor.authorAkdaǧ, Mehmet Zülküf
dc.contributor.authorDaşdağ, Süleyman
dc.contributor.orcid0000-0002-3321-2873
dc.contributor.orcid0000-0003-2826-2734
dc.contributor.orcid0000-0003-1211-9677
dc.date.accessioned2024-04-24T15:59:20Z
dc.date.available2024-04-24T15:59:20Z
dc.date.issued2021
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractThe continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR) emitted by cell phones on health. Several in vitro and in vivo studies have claimed that MWR may cause various kinds of damage in tissues. The aim of this study is to examine the possible effects of exposure to low-intensity MWR on DNA and oxidative damage in the livers of rats. Eighteen Sprague-Dawley male rats were divided into three equal groups randomly (n = 6). Group 1 (Sham-control): rats were kept under conditions the same as those of other groups, except for MWR exposure. Group 2: rats exposed to 1800 MHz (SAR: 0.62 W/kg) at 0.127 +/- 0.04 mW/cm(2) power density, and Group 3: rats exposed to 2,100 MHz (SAR: 0.2 W/kg) at 0.038 +/- 0.03 mW/cm(2) power density. Microwave application groups were exposed to MWR 2 h/day for 7 months. At the end of the exposure period, the rats were sacrificed and DNA damage, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and total oxidant-antioxidant parameter analyses were conducted in their liver tissue samples. It was found that 1800 and 2100 MHz low-intensity MWR caused a significant increase in MDA, 8-OHdG, total oxidant status, oxidative stress index, and comet assay tail intensity (P < 0.05), while total antioxidant status levels (P < 0.05) decreased. The results of our study showed that whole-body exposure to 1800 and 2100 MHz low-intensity MWR emitted by cell phones can induce oxidative stress by altering oxidant-antioxidant parameters and lead to DNA strand breaks and oxidative DNA damage in the liver of rats. Bioelectromagnetics. (c) 2020 Bioelectromagnetics Societyen_US
dc.identifier.citationAlkış, M. E., Akdaǧ, M. Z. ve Daşdağ, S. (2021). Effects of low-intensity microwave radiation on oxidant-antioxidant parameters and DNA damage in the liver of rats. Bioelectromagnetics, 42(1), 76-85.
dc.identifier.doi10.1002/bem.22315
dc.identifier.endpage85en_US
dc.identifier.issn0197-8462
dc.identifier.issn1521-186X
dc.identifier.issue1en_US
dc.identifier.pmid33368426
dc.identifier.scopus2-s2.0-85097998941
dc.identifier.scopusqualityQ2
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.1002/bem.22315
dc.identifier.urihttps://hdl.handle.net/11468/13990
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/bem.22315
dc.identifier.volume42en_US
dc.identifier.wosWOS:000601618000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkdaǧ, Mehmet Zülküf
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBioelectromagnetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrowave radiationen_US
dc.subjectLiveren_US
dc.subjectDna damageen_US
dc.subject8-OHdGen_US
dc.subjectMdaen_US
dc.titleEffects of low-intensity microwave radiation on oxidant-antioxidant parameters and DNA damage in the liver of ratsen_US
dc.titleEffects of low-intensity microwave radiation on oxidant-antioxidant parameters and DNA damage in the liver of rats
dc.typeArticleen_US

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