The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats

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dc.contributor.authorUzar, Ertugrul
dc.contributor.authorAcar, Abdullah
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorFirat, Ugur
dc.contributor.authorKamasak, Kagan
dc.contributor.authorGocmez, Cuneyt
dc.contributor.authorAlp, Harun
dc.date.accessioned2024-04-24T16:18:17Z
dc.date.available2024-04-24T16:18:17Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this experiment was to investigate whether nebivolol and zofenopril have protective effects against oxidative damage and apoptosis induced by cerebral ischemia/reperfusion (I/R). There were seven groups of rats, with each containing eight rats. The groups were: the control group, I/R group, I/R plus zofenopril, I/R plus nebivolol, I/R plus nebivolol and zofenopril. zofenopril only and nebivolol only. Cerebral I/R was induced by clamping the bilateral common carotid artery and through hypotension. The rats were sacrificed 1 h after ischemia, and histopathological and biochemical analyses were carried out on their brains. The total antioxidant capacity was evaluated by using an automated and colorimetric measurement method developed by Erel. I/R produced a significant increase in the levels of total oxidant status and malondialdehyde levels, the number of caspase-3 immunopositive cells and activities of prolidase and paraoxonase in brain when compared with the control group (p<0.05). A significant decrease in brain total antioxidant capacity and nitric oxide levels were found in I/R group when compared with the control group (p<0.05). Both nebivolol and zofenopril treatment prevented decreasing of the total antioxidant capacity and nitric oxide levels, produced by I/R in the brain (p<0.05). Both nebivolol and zofenopril treatment prevented the total oxidant status, malondialdehyde levels, activities of paraoxonase and prolidase from increasing in brains of rats exposed to I/R (p<0.05). In conclusion, both nebivolol and zofenopril protected rats from ischemia-induced brain injury. The protection may be due to the indirect prevention of oxidative stress and apoptosis. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Dicle University [2010-21]en_US
dc.description.sponsorshipThis research was part of a project that was financially supported by the Research Foundation of Dicle University (2010-21). We thank them for this support.en_US
dc.identifier.doi10.1016/j.pnpbp.2011.08.011
dc.identifier.endpage28en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue1en_US
dc.identifier.pmid21888941
dc.identifier.scopus2-s2.0-82555172350
dc.identifier.scopusqualityQ1
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2011.08.011
dc.identifier.urihttps://hdl.handle.net/11468/15949
dc.identifier.volume36en_US
dc.identifier.wosWOS:000300073000005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectNebivololen_US
dc.subjectOxidative Stressen_US
dc.subjectProlidaseen_US
dc.subjectZofenoprilen_US
dc.titleThe anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in ratsen_US
dc.titleThe anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats
dc.typeReview Articleen_US

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