Effect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver

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dc.contributor.authorAliosmanoglu, I.
dc.contributor.authorSevmis, S.
dc.contributor.authorKarakayali, H.
dc.contributor.authorKocbiyik, A.
dc.contributor.authorDagdeviren, A.
dc.contributor.authorHaberal, A.
dc.contributor.authorHaberal, M.
dc.date.accessioned2024-04-24T16:18:31Z
dc.date.available2024-04-24T16:18:31Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. The aim of this study was to investigate the effects of prostaglandin E-1 (PGE-1) on preservation injury in livers perfused with the University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Materials and methods. Five groups each including six rats included. Ringer's lactate RL (group 1), HTK (group 2), HTK + PGE-1 (group 3), UW (group 4), or UW PGE-1 (group 5). Liver tissue and preservation fluid samples were obtained from the perfused lives for pathological and biochemical examinations respectively at 0, 6 and 12 hours. Results. Upon biochemical examination, aspartate aminotrasnferase and alanine aminotransferase values were highest among the group with RL solution and lowest with PGE-1. Liver structure was found to be damaged immediately after RL solution, whereas it was preserved in the other four groups. Fewer cellular changes were reported at the end of 12 hours in the groups administered PGE-1 compared with the other groups. Conclusions. PGE-1 when applied before preservation protected liver functions, decreased pathologic injury, and delayed changes that occur under cold ischemic conditions.en_US
dc.description.sponsorshipAstellasen_US
dc.description.sponsorshipThe authors also thank to Professor Sule Oktay from Kappa Consultancy, Training and Research Ltd for her support in editing the manuscript funded by Astellas.en_US
dc.identifier.doi10.1016/j.transproceed.2012.05.093
dc.identifier.endpage2450en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue6en_US
dc.identifier.pmid23871184
dc.identifier.scopus2-s2.0-84882275952
dc.identifier.scopusqualityQ3
dc.identifier.startpage2446en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2012.05.093
dc.identifier.urihttps://hdl.handle.net/11468/16148
dc.identifier.volume45en_US
dc.identifier.wosWOS:000323852000066
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liveren_US
dc.titleEffect of Prostaglandin E-1 on Wisconsin University and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Preservation Injury of the Perfused Liver
dc.typeArticleen_US

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