Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats

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dc.contributor.authorTas, Mahmut
dc.contributor.authorGok, Ertugrul
dc.contributor.authorEkinci, Cenap
dc.contributor.authorDeveci, Engin
dc.contributor.authorDeveci, Senay
dc.date.accessioned2024-04-24T17:24:10Z
dc.date.available2024-04-24T17:24:10Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two groups: group 1 (control group), critical size cranial model with no treatment (n=10); group 2 (14-day synthetic graft group given 7th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) + Synthetic graft (n=10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general anesthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structures. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein astrocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic changes.en_US
dc.identifier.doi10.4067/S0717-95022016000100005
dc.identifier.endpage33en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84966549712
dc.identifier.scopusqualityQ3
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022016000100005
dc.identifier.urihttps://hdl.handle.net/11468/19489
dc.identifier.volume34en_US
dc.identifier.wosWOS:000375223700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalvarial Defectsen_US
dc.subjectRaten_US
dc.subjectCerebrumen_US
dc.subjectImmunohistochemistryen_US
dc.titleInvestigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Ratsen_US
dc.titleInvestigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
dc.typeArticleen_US

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