Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Chilena Anatomia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two groups: group 1 (control group), critical size cranial model with no treatment (n=10); group 2 (14-day synthetic graft group given 7th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) + Synthetic graft (n=10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general anesthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structures. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein astrocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic changes.
Açıklama
Anahtar Kelimeler
Calvarial Defects, Rat, Cerebrum, Immunohistochemistry
Kaynak
International Journal of Morphology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
34
Sayı
1
