Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorGokbel, Hakki
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBasarali, Kemal
dc.date.accessioned2024-04-24T16:19:02Z
dc.date.available2024-04-24T16:19:02Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the effects of grape seed extract (GSE) supplementation on exercise performance and oxidative stress in acutely and chronically exercised rats. A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic exercise control, acute exercise control (AEC), GSE-supplemented control, GSE-supplemented chronic exercise and GSE-supplemented acute exercise groups. Chronic exercise consisted of treadmill running at 25 m/min, 45 min/d, 5 d a week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. GSE were given at 100 mg/kg of body weight with drinking water for 6 weeks. Plasma was separated from blood samples for the analysis of oxidative stress markers. There was no significant difference in time of exhaustion between the acute exercise groups. Plasma malondialdehyde (MDA) levels were higher in the acute exercise groups and lower in the chronic exercise groups. GSE supplementation decreased MDA levels. Xanthine oxidase and adenosine deaminase activities were higher in the AEC group compared to all the other groups. NO levels were increased with both chronic exercise and GSE supplementation. Superoxide dismutase and glutathione peroxidase activities were lower in the acute exercised groups and higher in the chronic exercised groups. GSE supplementation caused an increase in antioxidant enzyme activities. In conclusion, GSE supplementation prevents exercise-induced oxidative stress by preventing lipid peroxidation and increasing antioxidant enzyme activities.en_US
dc.description.sponsorshipSelcuk University [SABE 08102008]en_US
dc.description.sponsorshipThe authors declare that there are no conflicts of interest. The authors thank Professor Said Bodur for the statistical assistance. This work was supported by Scientific Research and Project Coordinator of Selcuk University (grant no. SABE 08102008). All the authors contributed to the collection and interpretation of the data as well as to the drafting of the manuscript.en_US
dc.identifier.doi10.1017/S0007114511005496
dc.identifier.endpage256en_US
dc.identifier.issn0007-1145
dc.identifier.issue2en_US
dc.identifier.pmid22011589
dc.identifier.scopus2-s2.0-84863848984
dc.identifier.scopusqualityQ1
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.1017/S0007114511005496
dc.identifier.urihttps://hdl.handle.net/11468/16376
dc.identifier.volume108en_US
dc.identifier.wosWOS:000307171500008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofBritish Journal of Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrape Seed Extracten_US
dc.subjectExerciseen_US
dc.subjectOxidative Stressen_US
dc.titleEffects of grape seed extract supplementation on exercise-induced oxidative stress in ratsen_US
dc.titleEffects of grape seed extract supplementation on exercise-induced oxidative stress in rats
dc.typeArticleen_US

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