Lipid peroxidation markers in adult attention deficit hyperactivity disorder: New findings for oxidative stress

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dc.contributor.authorBulut, Mahmut
dc.contributor.authorSelek, Salih
dc.contributor.authorBez, Yasin
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorGunes, Mehmet
dc.contributor.authorKarababa, Fatih
dc.contributor.authorCelik, Hakim
dc.date.accessioned2024-04-24T16:18:18Z
dc.date.available2024-04-24T16:18:18Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractMalondialdehyde (MDA) is a reliable marker of lipid peroxidation where paraoxonase and arylesterase are two enzymes against it. Although increased MDA has been previously shown in adults with attention deficit/hyperactivity disorder (A-ADHD), levels of paraoxonase and arylesterase enzymes have not been studied yet. We aimed to determine the status of both MDA level and paraoxonase and arylesterase enzyme activities in A-ADHD patients. A total of 35 adults with ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV) criteria and 29 healthy volunteers were included in the study. Serum MDA, paraoxonase and arylesterase levels of the participants were measured. The disease severity of the patients was determined by using Turgay's Adult Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) DSM IV Based Diagnostic Screening and Rating Scale. The serum MDA level of patients was significantly higher than that of healthy control subjects, whereas their paraoxonase and arylesterase levels were significantly lower. There was no correlation between the levels of biochemical parameters (MDA, paraoxonase and arylesterase) and the disease severity. Sub-types of A-ADHD were similar in terms of these biochemical parameters. Increased lipid peroxidation, a part of oxidative stress, in adults with ADHD appears to be unbuffered by antioxidant enzymes, namely paraoxonase and arylesterase. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.psychres.2013.02.025
dc.identifier.endpage642en_US
dc.identifier.issn0165-1781
dc.identifier.issue3en_US
dc.identifier.pmid23680468
dc.identifier.scopus2-s2.0-84885473469
dc.identifier.scopusqualityQ1
dc.identifier.startpage638en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2013.02.025
dc.identifier.urihttps://hdl.handle.net/11468/15976
dc.identifier.volume209en_US
dc.identifier.wosWOS:000326766300060
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalondialdehydeen_US
dc.subjectParaoxonaseen_US
dc.subjectArylesteraseen_US
dc.subjectAdult Adhden_US
dc.subjectLipid Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.titleLipid peroxidation markers in adult attention deficit hyperactivity disorder: New findings for oxidative stressen_US
dc.titleLipid peroxidation markers in adult attention deficit hyperactivity disorder: New findings for oxidative stress
dc.typeArticleen_US

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