Sheehan's syndrome and its impact on bone mineral density

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dc.contributor.authorGokalp, Deniz
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahceci, Mithat
dc.contributor.authorArikan, Senay
dc.contributor.authorOzmen, Cihan Akgul
dc.contributor.authorCil, Timucin
dc.date.accessioned2024-04-24T16:24:44Z
dc.date.available2024-04-24T16:24:44Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction. Although there have been few studies investigating osteoporosis in isolated hormone deficiencies or other causes of hypopituitarism, the relationship between Sheehan's syndrome (SS) and osteoporosis has not been investigated. In the present study, we aimed to evaluate bone mineral density (BMD) in patients with SS in comparison with healthy women. Methods. Sixty-one patients with SS and 62 matched healthy controls were included. Biochemical, hormonal assessments and BMD evaluations were carried out in patients and controls, and a subgroup analysis according to menopausal status was done (premenopausal < 50 years; postmenopausal > 50 years). Results. The mean levels of serum anterior pituitary hormones were significantly lower in pre- and postmenopausal patients with SS compared with respective control groups (p < 0.0001). For both pre- and postmenopausal subjects, compared with respective controls, serum calcium and ALP levels, femur-T score, femur-Z score, spine (L1-L5)-T score, spine (L1-L5)-Z score and BMD values were lower, and phosphorus and parathyroid hormone (PTH) levels were higher in patients with SS. Conclusions. Patients with SS had low BMD. The possible mechanism responsible for osteoporosis may be hypogonadism, growth hormone deficiency and disorders of parathyroid hormone and calcium metabolism. But the contribution of each anterior pituitary hormone deficiency on bone loss should be clarified in further prospective studies.en_US
dc.identifier.doi10.1080/09513590802630096
dc.identifier.endpage349en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue5en_US
dc.identifier.pmid19903041
dc.identifier.scopus2-s2.0-67651102674
dc.identifier.scopusqualityQ2
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.1080/09513590802630096
dc.identifier.urihttps://hdl.handle.net/11468/16835
dc.identifier.volume25en_US
dc.identifier.wosWOS:000268186100011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Mineral Densityen_US
dc.subjectOsteoporosisen_US
dc.subjectPthen_US
dc.subjectSheehan's Syndromeen_US
dc.titleSheehan's syndrome and its impact on bone mineral densityen_US
dc.titleSheehan's syndrome and its impact on bone mineral density
dc.typeArticleen_US

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