Risk factors for neurologic sequelae in children and adolescents with hemophilia after intracranial hemorrhage

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dc.authoridAkbayram, Sinan/0009-0001-0816-4144
dc.authoridAlbayrak, Davut/0000-0002-7947-3817
dc.contributor.authorEvim, Melike Sezgin
dc.contributor.authorUnuvar, Aysegul
dc.contributor.authorAlbayrak, Canan
dc.contributor.authorZengin, Emine
dc.contributor.authorYilmaz, Ebru
dc.contributor.authorKaya, Zuhre
dc.contributor.authorKaradas, Nihal
dc.date.accessioned2025-02-22T14:08:59Z
dc.date.available2025-02-22T14:08:59Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Intracranial hemorrhage (ICH) is reportedly rare but has high morbidity and mortality risk in persons with hemophilia. Although the risk factors that facilitate bleeding are known, the factors affecting the sequelae are not well known. Objectives: We planned to investigate the risk factors for neurologic sequelae in children and adolescents with hemophilia suffering from ICH. Methods: An invitation was sent to pediatric hematology centers via email. Clinical and laboratory findings, neurologic sequelae, and recurrence of bleeding in persons with hemophilia who developed ICH were questioned. Results: Eighty-six patients from 21 centers were evaluated. All patients were less than 18 years of age at the time of ICH. Thirteen patients had ICH in the neonatal period, while 40 patients had a known diagnosis of hemophilia before ICH, and 33 patients were undiagnosed before ICH. Five patients died, 2 of whom died in the neonatal period. The rate of neurologic sequelae was 25 of 81 (30%). The most common neurologic sequela was epilepsy (n = 11/25), followed by hemiparesis (n = 5/25). Cerebral shift (odds ratio, 3.48) and development of ICH in the neonatal period (odds ratio, 4.67) were significant for the development of neurologic sequelae in multivariate analysis. On follow-up, recurrence of ICH occurred in 8 of 81 (10%). Conclusion: ICH in the neonatal period and cerebral shift were the two main risk factors for the development of neurologic sequelae. Neonatal departments must be alert to the signs of bleeding. It is important for healthcare professionals to overcome the barriers to primary prophylaxis and to take trauma-related precautions.en_US
dc.identifier.doi10.1016/j.rpth.2024.102607
dc.identifier.issn2475-0379
dc.identifier.issue8en_US
dc.identifier.pmid39687930en_US
dc.identifier.scopus2-s2.0-85210283626en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.rpth.2024.102607
dc.identifier.urihttps://hdl.handle.net/11468/29746
dc.identifier.volume8en_US
dc.identifier.wosWOS:001371095900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofResearch and Practice in Thrombosis and Haemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectadolescentsen_US
dc.subjectchildrenen_US
dc.subjecthemophiliaen_US
dc.subjectintracranial hemorrhageen_US
dc.subjectoutcomeen_US
dc.titleRisk factors for neurologic sequelae in children and adolescents with hemophilia after intracranial hemorrhageen_US
dc.typeArticleen_US

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