Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study

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dc.contributor.authorErdem, Hakan
dc.contributor.authorOzturk-Engin, Derya
dc.contributor.authorTireli, Hulya
dc.contributor.authorKilicoglu, Gamze
dc.contributor.authorDefres, Sylviane
dc.contributor.authorGulsun, Serda
dc.contributor.authorSengoz, Gonul
dc.date.accessioned2024-04-24T16:01:53Z
dc.date.available2024-04-24T16:01:53Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractPredicting unfavorable outcome is of paramount importance in clinical decision making. Accordingly, we designed this multinational study, which provided the largest case series of tuberculous meningitis (TBM). 43 centers from 14 countries (Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria, Turkey) submitted data of microbiologically confirmed TBM patients hospitalized between 2000 and 2012. Unfavorable outcome was defined as survival with significant sequela or death. In developing our index, binary logistic regression models were constructed via 200 replicates of database by bootstrap resampling methodology. The final model was built according to the selection frequencies of variables. The severity scale included variables with arbitrary scores proportional to predictive powers of terms in the final model. The final model was internally validated by bootstrap resampling. A total of 507 patients' data were submitted among which 165 had unfavorable outcome. Eighty-six patients died while 119 had different neurological sequelae in 79 (16 %) patients. The full model included 13 variables. Age, nausea, vomiting, altered consciousness, hydrocephalus, vasculitis, immunosuppression, diabetes mellitus and neurological deficit remained in the final model. Scores 1-3 were assigned to the variables in the severity scale, which included scores of 1-6. The distribution of mortality for the scores 1-6 was 3.4, 8.2, 20.6, 31, 30 and 40.1 %, respectively. Altered consciousness, diabetes mellitus, immunosuppression, neurological deficits, hydrocephalus, and vasculitis predicted the unfavorable outcome in the scoring and the cumulative score provided a linear estimation of prognosis.en_US
dc.identifier.doi10.1007/s00415-015-7651-5
dc.identifier.endpage898en_US
dc.identifier.issn0340-5354
dc.identifier.issn1432-1459
dc.identifier.issue4en_US
dc.identifier.pmid25634680
dc.identifier.scopus2-s2.0-84939967510
dc.identifier.scopusqualityQ1
dc.identifier.startpage890en_US
dc.identifier.urihttps://doi.org/10.1007/s00415-015-7651-5
dc.identifier.urihttps://hdl.handle.net/11468/14458
dc.identifier.volume262en_US
dc.identifier.wosWOS:000353295400011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTuberculosisen_US
dc.subjectMeningitisen_US
dc.subjectDeathen_US
dc.subjectOutcomeen_US
dc.subjectSequelaeen_US
dc.titleHamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II studyen_US
dc.titleHamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study
dc.typeArticleen_US

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