Localization of Estrogen Receptor Alpha and Progesterone Receptor B in the Bovine Ovary During the Follicular and Luteal Phase of the Sexual Cycle

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dc.contributor.authorAkbalik, Mehmet Erdem
dc.contributor.authorSagsoz, Hakan
dc.contributor.authorSaruhan, Berna Guney
dc.date.accessioned2024-04-24T17:37:37Z
dc.date.available2024-04-24T17:37:37Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractOvarian steroid hormones, mainly estrogen and progesterone, play a central role in the regulation of ovarian functions. The biological effects of progesterone (PR) and estrogen (ER) are dependent on the activation of both PR and ER isoforms. In the present study, we studied the cellular distribution and localization of progesterone receptor B (PR-B) and estrogen receptor alpha (ER alpha) in the bovine ovaries during the follicular and luteal phases of the sexual cycle using immunohistochemical methods. The estrous cycle stage of 23 Holstein bovines was evaluated by gross and histological appearance of ovaries and blood steroid hormone values. Tissue samples from ovaries were fixed in 10% formaldehyde for routine histological processing. ERa immunoreactivity was observed in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, epithelial cells of the germinal epithelium, stroma cells, theca cells, corpora lutea cells and cells of the corpora albicantia. Nuclear staining for PR-B was not detected in the granulosa cells in all sizes of follicles, but was positively stained in germinal epithelium cells, stroma cells, corpora albicantia cells and corpora lutea cells. In conclusion, ER alpha and PR-B immunoreactivity in bovine ovary were not indicate too much difference between the phases of the sexual cycle but have important differences in cell-spesific localization.en_US
dc.identifier.endpage802en_US
dc.identifier.issn1300-6045
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-80052158387
dc.identifier.scopusqualityQ3
dc.identifier.startpage795en_US
dc.identifier.urihttps://hdl.handle.net/11468/21070
dc.identifier.volume17en_US
dc.identifier.wosWOS:000295359100018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBovine Ovaryen_US
dc.subjectEstrogen Receptoren_US
dc.subjectProgesterone Receptoren_US
dc.subjectImmunohistochemistryen_US
dc.titleLocalization of Estrogen Receptor Alpha and Progesterone Receptor B in the Bovine Ovary During the Follicular and Luteal Phase of the Sexual Cycleen_US
dc.titleLocalization of Estrogen Receptor Alpha and Progesterone Receptor B in the Bovine Ovary During the Follicular and Luteal Phase of the Sexual Cycle
dc.typeArticleen_US

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