Exploring the role of immune biomarkers in idiopathic granulomatous mastitis: A clinical and pathological perspective

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dc.authorid0000-0001-9762-2401
dc.authorid0000-0001-8155-8310
dc.authorid0000-0001-5529-4155
dc.authorid0000-0003-4462-5953
dc.contributor.authorAydın, Umut
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorArtaş, Hakan
dc.contributor.authorArtaş, Gökhan
dc.contributor.authorÖz, Burak
dc.contributor.authorAydoğdu, Mesude Seda
dc.contributor.authorAkkoç, Ramazan Fazıl
dc.contributor.authorAkar, Zeynel Abidin
dc.date.accessioned2025-02-22T14:09:01Z
dc.date.available2025-02-22T14:09:01Z
dc.date.issued2025
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.description.abstractBackground: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disorder characterised by the formation of non-caseating granulomas in breast tissue, primarily affecting young women of childbearing age. The aetiology of IGM remains unclear, with potential factors including trauma, hormonal influences, and autoimmune responses. Recent studies suggest that immune dysregulation may play a critical role in IGM, highlighting the need for exploration of biomarkers involved in inflammation and immune modulation, particularly LL-37, galectin-3, IL-36, and TLR3. Methods: This study included 36 patients diagnosed with IGM and 37 healthy controls. Blood samples were collected from all participants, and serum levels of LL-37, IL-36 alpha, galectin-3, and TLR3 were analyzed using enzyme-linked immunosorbent assay (ELISA). Immunohistochemical evaluations were conducted on breast tissue samples from 16 IGM patients and 10 controls who underwent mammoplasty. Clinical data, including laboratory tests and imaging results, were also collected and analyzed. Statistical analyses were performed using the IBM-SPSS-22.0 software, with significance set at p < 0.05. Results: Serum levels of LL-37, IL-36 alpha, galectin-3, and TLR3 were significantly lower in IGM patients compared to healthy controls (p < 0.001 for all). Immunohistochemical analysis revealed reduced expression of LL-37 in IGM tissue samples, while galectin-3 levels were comparable between the IGM and control groups (p = 0.32). Clinical evaluations indicated significant improvements in inflammatory markers (CRP and ESR) and mass size over the treatment period. Conclusions: The findings of this study suggest that LL-37, IL-36 alpha, galectin-3, and TLR3 are implicated in the pathogenesis of IGM, with their serum levels being significantly diminished in affected patients. The observed reduction in LL-37 may contribute to the decline in IL-36 alpha and TLR3 levels, indicating a potential role of these biomarkers in the inflammatory processes associated with IGM. Further research is warranted to elucidate the mechanisms underlying these alterations and their implications for the diagnosis and treatment of IGM.en_US
dc.identifier.citationAydın, U., Karataş, A., Artaş, G., Öz, B., Aydoğdu, M. S., Artaş, H. ve diğerleri. (2025). “Exploring the role of immune biomarkers in idiopathic granulomatous mastitis: A clinical and pathological perspective”. Human Immunology, 86(1), 1-7.
dc.identifier.doi10.1016/j.humimm.2024.111222
dc.identifier.issn0198-8859
dc.identifier.issn1879-1166
dc.identifier.issue1en_US
dc.identifier.pmid39740302en_US
dc.identifier.scopus2-s2.0-85213280099en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.humimm.2024.111222
dc.identifier.urihttps://hdl.handle.net/11468/29761
dc.identifier.volume86en_US
dc.identifier.wosWOS:001404194600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkar, Zeynel Abidin
dc.institutionauthorid0000-0001-8155-8310
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofHuman Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectAnti-citrullinated protein antibodyen_US
dc.subjectLL-37en_US
dc.subjectIL-36 alphaen_US
dc.subjectGalectin-3en_US
dc.subjectTLR3en_US
dc.subjectImmune biomarkeren_US
dc.titleExploring the role of immune biomarkers in idiopathic granulomatous mastitis: A clinical and pathological perspectiveen_US
dc.typeArticleen_US

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