Histopathological, antioxidant, and enzyme activity of boronic incorporated catechin compound: Screening of bioactivity with molecular docking studies

Basit Öğe Kaydı
dc.authorid0000-0002-4792-8821en_US
dc.authorid0000-0001-9225-7425en_US
dc.authorid0000-0002-2193-8386en_US
dc.contributor.authorPaşa, Salih
dc.contributor.authorAtlan, Metin
dc.contributor.authorTemel, Hamdi
dc.contributor.authorTürkmenoğlu, Burçin
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorOkan, Aslı
dc.contributor.authorYılmaz, Seher
dc.contributor.authorAteş, Şükrü
dc.date.accessioned2024-08-19T11:28:12Z
dc.date.available2024-08-19T11:28:12Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Ana Bilim Dalıen_US
dc.description.abstractAbstract: Objective: Boron structures play a crucial role in biological treatments due to their unique chemical properties. They are used in pharmaceuticals for their potential as enzyme inhibitors and as anti-inflammatory agents. Boron-containing compounds are also explored in drug delivery systems, leveraging their ability to cross cell membranes effectively. Additionally, boron-based materials are studied for their applications in biomaterials, such as wound healing and tissue engineering, highlighting their diverse applications in biological treatments. Methods: The study aims to elucidate the biological properties of catechin, a natural phenolic compound, by modifying it with phenylboronic acid. The Catechin-based boronic compound (CBC) was synthesized. The antioxidant and enzyme activity were studied. Histopathological experiments to vital organs and molecular docking studies were also conducted. Results and Discussion: The (CBC) showed meaningful antioxidant and enzyme activity when compared to standards. The effect of the (CBC) on tissues was demonstrated by in vivo experiments. Histopathological evaluation of vital organs in male Sprague Dawley rats was demonstrated by Hematoxylin–Eosin staining. The study has supported the antioxidant property of (CBC), also has a natural origin based on its structure. Besides, the antiurease and antityrosinase activities of catechin were tested for the first time. Furthermore, in silico approaches also supported the acceptable biological activity results that were experimentally examined. The interactions of AChE, BChE, urease, and tyrosinase enzymes with the (CBC) were investigated theoretically via molecular docking, and the binding parameter values were also shared. The (CBC) demonstrated radical scavenging activity. The in vivo experiments on rats were carried out and the (CBC) showed no negative effects on the vital organs. It was seen that the experimental results were in good agreement with the theoretical calculations. Conclusions: The analysis of the crystal structures of AChE, BChE, urease, and tyrosinase enzymes in relation to the compound (CBC) yielded striking results, highlighting the compound’s promising potential as a therapeutic agent.en_US
dc.identifier.citationPaşa, S., Atlan, M., Temel, H., Türkmenoğlu, B., Ertaş, A., Okan, A. ve diğerleri. (2024). Histopathological, antioxidant, and enzyme activity of boronic incorporated catechin compound: Screening of bioactivity with molecular docking studies. Russian Journal of Bioorganic Chemistry, 50(4), 1446-1465.en_US
dc.identifier.endpage1465en_US
dc.identifier.issn1068-1620
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85200448505
dc.identifier.scopusqualityQ4
dc.identifier.startpage1446en_US
dc.identifier.urihttps://link.springer.com/article/10.1134/S1068162024040216
dc.identifier.urihttps://hdl.handle.net/11468/28762
dc.identifier.volume50en_US
dc.identifier.wosWOS:001284717400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAtlan, Metin
dc.institutionauthorErtaş, Abdulselam
dc.language.isoenen_US
dc.publisherPleiades Publishingen_US
dc.relation.ispartofRussian Journal of Bioorganic Chemistry
dc.relation.isversionof10.1134/S1068162024040216en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectBoronic aciden_US
dc.subjectCatechinen_US
dc.subjectEnzyme activityen_US
dc.subjectHistopathologyen_US
dc.subjectMolecular dockingen_US
dc.titleHistopathological, antioxidant, and enzyme activity of boronic incorporated catechin compound: Screening of bioactivity with molecular docking studiesen_US
dc.titleHistopathological, antioxidant, and enzyme activity of boronic incorporated catechin compound: Screening of bioactivity with molecular docking studies
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Histopathological, Antioxidant, and Enzyme Activity of Boronic Incorporated Catechin Compound Screening of Bioactivity with Molecular Docking Studies.pdf
Boyut:
7.77 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Fen Bilimleri Enstitüsü Makaleler
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu