Proposal of a diagnostic test for the detection of preterm premature rupture of membranes based on the determination of thyroid hormones in vaginal washing fluid

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dc.contributor.authorKale, Ahmet
dc.contributor.authorKale, Ebru
dc.contributor.authorAkdeniz, Nurten
dc.contributor.authorKuyumcuoglu, U.
dc.contributor.authorCanoruc, N.
dc.date.accessioned2024-04-24T17:14:27Z
dc.date.available2024-04-24T17:14:27Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To determine whether measurement of total T3 (triiodothyronine), total T4 (thyroxine), free T3 (free triiodothyronine) and free T4 (free thyroxine) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (PPROM). Study Design: The PPROM group and normal pregnancy group consisted of 30 and 30 pregnant patients between 26 and 36 weeks' gestation, respectively. Vaginal fluid total T4, free T4, total T3 and free T3 levels were measured in both groups. Results: Vaginal fluid total T3 and free T3 levels were not statistically significant in the PPROM group as compared with the control group (p = 0.087, p = 0.123, respectively). Vaginal fluid total T4 and free T4 levels were significantly higher in the PPROM group as compared with the control group (p = 0.002, p < 0.000, respectively). The optimal cut-off value for total T4 (0.866 mu g/dl) gave a sensitivity level of 83.3% (65.3-94.3, 95% CI) at a specificity of 60.0% (40.6-77.3, 95% CI) with positive and negative predictive values of 67.6 and 78.3%, respectively. The optimal cut-off value for free T4 ( 0.079 ng/dl) gave a sensitivity level of 90% (73.4-97.8, 95% CI) at a specificity of 70.0% (50.6-85.2, 95% CI) with positive and negative predictive values of 75.0 and 87.5%, respectively. Conclusions: Total and free T4 measurements from vaginal fluids appears to be a useful marker of PPROM. Copyright (c) 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000103290
dc.identifier.endpage334en_US
dc.identifier.issn1015-3837
dc.identifier.issn1421-9964
dc.identifier.issue5en_US
dc.identifier.pmid17556818
dc.identifier.scopus2-s2.0-34547934662
dc.identifier.scopusqualityQ1
dc.identifier.startpage330en_US
dc.identifier.urihttps://doi.org/10.1159/000103290
dc.identifier.urihttps://hdl.handle.net/11468/17953
dc.identifier.volume22en_US
dc.identifier.wosWOS:000248239100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofFetal Diagnosis and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreterm Premature Rupture Of Membranesen_US
dc.subjectTotal T3, T4en_US
dc.subjectFree T3, T4en_US
dc.titleProposal of a diagnostic test for the detection of preterm premature rupture of membranes based on the determination of thyroid hormones in vaginal washing fluiden_US
dc.titleProposal of a diagnostic test for the detection of preterm premature rupture of membranes based on the determination of thyroid hormones in vaginal washing fluid
dc.typeArticleen_US

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