Is serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease?

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dc.contributor.authorBahceci, M
dc.contributor.authorTuzcu, A
dc.contributor.authorOgun, C
dc.contributor.authorCanoruc, N
dc.contributor.authorIltimur, K
dc.contributor.authorAslan, C
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and aims: C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent. We aimed to compare serum high sensitivity CRIP (hs-CRP) levels in Type 2 diabetic (T2DM) men without CHD, non-diabetic CHD patients and T2DM patients with CHD. Subjects and methods: Four groups were formed; Group 1 [DM(+) CHD(-), no.=25], Group 2 [DM(-) CHD(+) no.=25], Group 3 [DM(+), CHD(+), no.=25], and Group 4 (controls, no.=30). Serum hs-CRP, insulin, glucose, total, HDL-, LDL- and VLDL-cholesterol, triglyceride levels and homeostasis model assessment for insulin resistance (HOMA-IR) index were determined. Results: Mean hs-CRP level of Group 1 (0.6 +/- 0.29) was not different statistically from Group 2 (1.44 +/- 0.97). Mean hs-CRP levels were higher in men with CHD, whether they were diabetic (Group 3; 3.83 +/- 2.01 mg/dl) or non-diabetic (Group 4), than in control subjects (0.16 +/- 0.15; p=0.0001 and p < 0.004, respectively). Mean hs-CRP level of Group 3 was also higher than Group 2 (p=0.0001). There was a positive correlation between serum hs-CRP and glycated hemoglobin (HbA(1c); r=0.277, p < 0.01), fasting insulin (r=0.336, p < 0.02) and HOMA-IR (r=0.348, p < 0.02) in T2DM men with or without CHD. Conclusions: T2DM men without CHD had similar CRP levels with non-diabetic CHD patients, whereas CRP levels of T2DM men with CHD were higher than non-diabetic men with CHD. Because of a positive correlation between serum hs-CRP and HbA(1c) fasting insulin and HOMA-IR, inflammation, insulin resistance and hyperglycemia jointly contribute to the cardiovascular risk in T2DM men. (c) 2005, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03345357
dc.identifier.endpage150en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue2en_US
dc.identifier.pmid15887860
dc.identifier.scopus2-s2.0-20444465303
dc.identifier.scopusqualityQ1
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345357
dc.identifier.urihttps://hdl.handle.net/11468/14208
dc.identifier.volume28en_US
dc.identifier.wosWOS:000228735600008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 Diabetesen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectHoma-Iren_US
dc.subjectHba(1c)en_US
dc.titleIs serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease?en_US
dc.titleIs serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease?
dc.typeArticleen_US

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