Effect of Pleurotus ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteers

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dc.authoridArslan, Nurgul/0000-0002-7618-0859
dc.authoridYAPRAK, BULENT/0000-0001-5592-9755
dc.authoridYALCIN, PINAR/0000-0003-2503-6993
dc.authoridDUNDAR, ABDURRAHMAN/0000-0002-7930-1054
dc.authoridKarahan, Selim/0000-0001-5784-7091
dc.authoridBoga, Mehmet/0000-0003-4163-9962
dc.authoridACAY, Hilal/0000-0002-7732-106X
dc.contributor.authorDundar, Abdurrahman
dc.contributor.authorYalcin, Pinar
dc.contributor.authorArslan, Nurgul
dc.contributor.authorAcay, Hilal
dc.contributor.authorHatipoglu, Abdulkerim
dc.contributor.authorBoga, Mehmet
dc.contributor.authorKarahan, Selim
dc.date.accessioned2025-02-22T14:08:54Z
dc.date.available2025-02-22T14:08:54Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Our aim in this study is, does 29-day regular consumption of Pleurotus ostreatus water extract by volunteer individuals who meet the study criteria have an effect on blood and cytokine values? Method: In accordance with the purpose of the study, volunteers were asked to consume 100 ml of the extract every morning for 29 days. Three tubes of blood samples were taken from the volunteers on the 15th and 29th days of the study. Biochemical and hematological analysis of the blood samples were performed and immunomodulatory effects through cytokines were examined. The values obtained from 3 tubes of blood obtained from volunteers before the use of mushroom extract were used as control. The chemical composition and beta-glucan content of 100 ml of mushroom water extract were also analyzed. Result: IL-4, IL-6, IL-10 and IL-13 could not be detected because the values were below the lowest standard value. TNF-alpha, IFN-gamma and IL-1 beta 15th and 29th day values decreased compared to the 1st day (control) values (p < 0.05). However, there was no significant difference observed between the 15th and 29th day. No abnormalities were observed in biochemical and hematological values. Also, the beta-glucan content of extract was found 38.12 mg/100 ml. Conclusion: The frequency range of kidney and liver function test results confirmed that P. osreatus is a reliable food source. Considering the cytokine values these results indicate that P. ostreatus water extract has an anti-inflammatory effect. As no significant difference was observed in 29 days of use, it is thought that 15 days of daily consumption of the extract may be sufficient for the anti-inflammatory effect to occur. However, a large number of qualified clinical trials are needed to support the issue.en_US
dc.description.sponsorshipMardin Artuklu University Scientific Research Projects Coordination Unit [MAU.BAP.22.SHMYO.021]en_US
dc.description.sponsorshipThis study was carried out with the support by Mardin Artuklu University Scientific Research Projects Coordination Unit within the scope of the project numbered MAU.BAP.22.SHMYO.021. We take this opportunity to thank the unit.en_US
dc.identifier.doi10.1080/27697061.2024.2369781
dc.identifier.endpage652en_US
dc.identifier.issn2769-7061
dc.identifier.issn2769-707X
dc.identifier.issue8en_US
dc.identifier.pmid38935369en_US
dc.identifier.scopus2-s2.0-85197392297en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage645en_US
dc.identifier.urihttps://doi.org/10.1080/27697061.2024.2369781
dc.identifier.urihttps://hdl.handle.net/11468/29707
dc.identifier.volume43en_US
dc.identifier.wosWOS:001258054800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherRoutledge Journals, Taylor & Francis Ltden_US
dc.relation.ispartofJournal of the American Nutrition Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectPleurotus ostreatusen_US
dc.subjectcytokineen_US
dc.subjectblood analysisen_US
dc.subjectimmunomodulatoren_US
dc.titleEffect of Pleurotus ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteersen_US
dc.typeArticleen_US

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