Ghrelin in the pilosebaceous unit: alteration of ghrelin in patients with acne vulgaris

Basit Öğe Kaydı
dc.contributor.authorCicek, Demet
dc.contributor.authorDemir, Betul
dc.contributor.authorErden, Ilker
dc.contributor.authorKuloglu, Tuncay
dc.contributor.authorUcer, Ozlem
dc.contributor.authorAydin, Suleyman
dc.contributor.authorUcak, Haydar
dc.date.accessioned2024-04-24T17:18:14Z
dc.date.available2024-04-24T17:18:14Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Ghrelin in the pilosebaceous tissues of human skin and ghrelin levels in patients with acne vulgaris have not yet been investigated. Objective: The purpose of this study was to screen ghrelin immunoreactivity by immunohistochemistry in human pilosebaceous tissues of human skin and also to determine the quantities of ghrelin in the serum of the patients with acne vulgaris. Methods: 30 patients presenting with acne vulgaris and 30 control subjects participated in this study. Ghrelin levels were determined by enzyme linked immunosorbent assay (ELISA). Human hair follicles and sebaceous glands were immunohistochemically examined. Results: Immunohistochemistry results showed that there is a strong ghrelin immunoreactivity in the hair follicles and sebaceous glands in sections of human skin. The mean serum ghrelin levels (27.58 +/- 15.44 pg/mL) in patients with acne vulgaris was significantly lower than those of controls (35.62 +/- 20.46 pg/mL). Conclusions: Ghrelin produced in hair follicles and sebaceous glands of the skin might participate in the pathogenesis of acne vulgaris and also acne vulgaris in humans might be associated with decreased serum ghrelin.en_US
dc.identifier.doi10.1684/ejd.2015.2574
dc.identifier.endpage328en_US
dc.identifier.issn1167-1122
dc.identifier.issn1952-4013
dc.identifier.issue4en_US
dc.identifier.pmid26629576
dc.identifier.scopus2-s2.0-84941763268
dc.identifier.scopusqualityQ3
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.1684/ejd.2015.2574
dc.identifier.urihttps://hdl.handle.net/11468/18680
dc.identifier.volume25en_US
dc.identifier.wosWOS:000362902100004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJohn Libbey Eurotext Ltden_US
dc.relation.ispartofEuropean Journal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne Vulgarisen_US
dc.subjectAntimicrobialen_US
dc.subjectGhrelinen_US
dc.subjectPilosebaceous Uniten_US
dc.titleGhrelin in the pilosebaceous unit: alteration of ghrelin in patients with acne vulgarisen_US
dc.titleGhrelin in the pilosebaceous unit: alteration of ghrelin in patients with acne vulgaris
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu