A Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profiling

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dc.authorid0000-0002-8325-8116en_US
dc.contributor.authorŞahin, Hasan
dc.contributor.authorDemir, Serhat
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorSarı, Aynur
dc.contributor.authorMakbul, Serdar
dc.contributor.authorCoşkunçelebi, Kamil
dc.date.accessioned2024-02-22T11:32:54Z
dc.date.available2024-02-22T11:32:54Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.description.abstractLeaves of Scorzonera incisa DC. (Asteraceae) are eaten raw against diabetes and headache. Evaluation of medicinal, edible plants using profiling methods has become a common phenomenon. Petroleum ether (PE), ethyl acetate (EA), and nbutanol (BU) fractions were prepared from ethanol extract of the aerial parts of the plant. Isolation by HPLC and phenolic profiling by validated LC-MS/MS method with 53 compounds were conducted on the EA fraction. GC-MS method was used to profile the PE fraction. In-vitro inhibitory activities of all fractions against α-amylase, α-glucosidase, AChE, BChE, tyrosinase and urease enzymes were measured. Isoorientin, vitexin, cynaroside and chlorogenic acid were isolated and characterized from the EA fraction as major compounds. LC-MS/MS analysis quantified 36 compounds in the EA fraction. 20 compounds were tentatively determined in the PE fraction. Compounds with the same molecular and fragment ions, a low percentage of identified compounds, and very close polarities were revealed to be some limits of the nature for LC-MS/MS profiling. Particularly, the presence and amount of substances other than the standard compounds used in the profiling methods and possible misdetections should not be neglected in evaluating medicinal plants and establishing a correlation between compounds and bioactivity.en_US
dc.identifier.citationŞahin, H., Demir, S., Boğa, M., Sarı, A., Makbul, S. ve Coşkunçelebi, K. (2023). A Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profiling. ChemistrySelect, 8(34), e202302173.en_US
dc.identifier.doi10.1002/slct.202302173
dc.identifier.endpage7en_US
dc.identifier.issn2365-6549
dc.identifier.issue34en_US
dc.identifier.scopus2-s2.0-85170027733
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202302173
dc.identifier.urihttps://hdl.handle.net/11468/13361
dc.identifier.volume8en_US
dc.identifier.wosWOS:001063794200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞahin, Hasan
dc.institutionauthorDemir, Serhat
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectScorzonera incisaen_US
dc.subjectPhytochemical Profilingen_US
dc.titleA Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profilingen_US
dc.titleA Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profiling
dc.typeArticleen_US

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