Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight

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dc.contributor.authorSaruhan, BG
dc.contributor.authorOzbag, D
dc.contributor.authorGumusalan, Y
dc.contributor.authorOzdemir, N
dc.date.accessioned2024-04-24T17:37:32Z
dc.date.available2024-04-24T17:37:32Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To determine the effect of flutamide on vaginal histology, and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model. Methods: We chose 36 sexually mature female Wistar-Albino rats in this study. The study took placed in the Department of Medical Science Application and Research Center of Dicle University, Diyarbakir, Turkey, in 2002. We divided the model rats into 3 groups: group 1 - control group, group 2 - sham-operated group and group 3 - bilaterally ovariectomized group. In addition, we gave flutamide to group 3. Results: We found that the body weight was higher in the ovariectomized rats than the control rats. Furthermore, the body weight decreased a little after flutamide therapy. The thickness in the vaginal epithelium of the control group decreased, moreover, the appearance of stromal tissue was rather loose. After flutamide applications, infiltration of the stromal cells increased, the vaginal epithelial layer thickened and became keratinized. Microscopic papillae and anatomical processes appeared in the flutamide treated group. Conclusion: We observed that the antiandrogen drug flutamide is hormonally active and may exhibit estrogenic-antiestrogenic activity in rats. Our study may be a source for further research examining the relationship between. the androgen receptor antagonist flutamide and reproductive function in female rats.en_US
dc.identifier.endpage1903en_US
dc.identifier.issn0379-5284
dc.identifier.issue12en_US
dc.identifier.pmid16380769
dc.identifier.scopus2-s2.0-31844442903
dc.identifier.scopusqualityQ2
dc.identifier.startpage1897en_US
dc.identifier.urihttps://hdl.handle.net/11468/21009
dc.identifier.volume26en_US
dc.identifier.wosWOS:000234848300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleInfluence of ovariectomy and flutamide treatment on vaginal tissue and body weighten_US
dc.titleInfluence of ovariectomy and flutamide treatment on vaginal tissue and body weight
dc.typeArticleen_US

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