Oxidative stress, inflammation and early cardiovascular damage in children with chronic renal failure

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dc.contributor.authorEce, A
dc.contributor.authorGürkan, F
dc.contributor.authorKervancioglu, M
dc.contributor.authorKocamaz, H
dc.contributor.authorGünes, A
dc.contributor.authorAtamer, Y
dc.contributor.authorSelek, S
dc.date.accessioned2024-04-24T16:01:54Z
dc.date.available2024-04-24T16:01:54Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe relationship between inflammation, oxidant stress and cardiovascular damage in children with chronic renal failure (CRF) has not previously been investigated. The aim of this study was to investigate markers of oxidative stress, inflammation and early cardiovascular abnormalities. Therefore, erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities; blood glutathione (GSH) and serum malondialdehyde (MDA) levels; C-reactive protein (CRP) and proinflammatory cytokines (IL-6, TNF-alpha,); and left ventricular masses (LVM) and intima media thicknesses (IMT) were measured in children with CRF. A total of 29 children with CRF (19 nondialysis, 10 peritoneal dialysis) were included. The control group consisted of 25 healthy subjects. CRF children had significantly increased IL-6, TNF-alpha, CRP and MDA concentrations and decreased SOD, CAT and GSH levels compared with controls (P < 0.05). Nondialysis and peritoneal dialysis subgroups had similar oxidative stress and inflammation biomarkers (P > 0.05). Erythrocyte CAT was positively correlated with CRP, TNF-alpha, and IL2-R in the study group. Positive correlations were found between cytokine concentrations, CRP and urea/creatinine levels. Significantly increased LVM and IMT values were found in CRF children (P < 0.05). In conclusion, increased oxidant stress and inflammation together with early cardiovascular damage were found in CRF children. Further studies with more patients are needed to verify these results.en_US
dc.identifier.doi10.1007/s00467-006-0039-0
dc.identifier.endpage552en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue4en_US
dc.identifier.pmid16520949
dc.identifier.scopus2-s2.0-33645374343
dc.identifier.scopusqualityQ1
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-006-0039-0
dc.identifier.urihttps://hdl.handle.net/11468/14484
dc.identifier.volume21en_US
dc.identifier.wosWOS:000236417600016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectChronic Renal Failureen_US
dc.subjectInflammationen_US
dc.subjectOxidative Stressen_US
dc.subjectLeft Ventricular Massen_US
dc.subjectIntima Media Thicknessen_US
dc.titleOxidative stress, inflammation and early cardiovascular damage in children with chronic renal failureen_US
dc.titleOxidative stress, inflammation and early cardiovascular damage in children with chronic renal failure
dc.typeArticleen_US

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